TRIM28 Recombinant Rabbit Monoclonal Antibody (SD081-05), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532378-Each-of-1 | In Stock | ₹ 46,413.50 |
PIMA532378 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
TRIM28
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
O08629, Q13263, Q62318
Gene Symbols
TRIM28
Immunogen
Synthetic peptide within Human KAP1 aa 301-350
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Flow Cytometry, Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
SD081-05
Conjugate
Unconjugated
Gene
TRIM28
Gene Alias
AA408787, E3 SUMO-protein ligase TRIM28, KAP1, KAP-1, KRAB [Kruppel-associated box domain]-associated protein 1, KRAB-A-interacting protein, KRAB-associated protein 1, KRAB-interacting p, KRAB-interacting protein 1, Krip1, KRIP-1, MommeD9, Nuclear corepressor KAP-1, PPP1R157, protein phosphatase 1, regulatory subunit 157, RING finger protein 96, RING-type E3 ubiquitin transferase TIF1-beta, RNF96, TF1B, tif1 beta, Tif1b, Tif1beta, TIF1-beta, Transcription intermediary factor 1-beta, transcriptional intermediary factor 1, beta, transcriptional intermediary factor 1-beta, Trim28, tripartite motif, tripartite motif containing 28, tripartite motif protein 28, tripartite motif-containing 28, tripartite motif-containing protein 28
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
10155, 116698, 21849
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- The KRAB (Kruppel-associated box) domain is about 45 amino acids in length and is a transcriptional repression domain found in numerous transcription factors
- There have been identified over 220 KRAB-zinc finger protein (KRAB-ZFP) genes in the human genome
- These proteins functionally repress transcription via specific interactions with KAP-1 (KRAB-associated protein 1)
- KAP-1 is an 835 amino acid polypeptide that contains a RING finger, B boxes, and a PHD finger
- KAP-1 has been shown to form complexes with KRAB-domain transcription factors and increase the efficiency with which they mediate repression
- KAP-1 has also been shown to directly interact with HP1 (heterochromatin protein 1) and KRAZ1 (Kruppel-associated box-containing zinc finger protein 1)
- KAP-1 directly targets KRAZ1 to the foci of centromeric heterochromatin containing HP1alpha, thus helping to regulate transcriptional repression
- Studies have shown that KAP-1 mutants with the ability to bind KRAB but unable to bind HP1 leads to random distribution of KRAZ1 and strong transcriptional activation.