PIMA533175
Phospho-IRF3 (Ser386) Recombinant Rabbit Monoclonal Antibody (4H10), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA533175-Each-of-1 | In Stock | ₹ 50,596.50 |
PIMA533175 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 50,596.50
GST (18%): ₹ 9,107.37
Total Price: ₹ 59,703.87
Antigen
Phospho-IRF3 (Ser386)
Classification
Recombinant Monoclonal
Concentration
1.03 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.4
Gene Accession No.
Q14653
Gene Symbols
IRF3
Immunogen
A synthesized peptide derived from human Phospho-IRF3 (S386)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
ELISA, Western Blot
Clone
4H10
Conjugate
Unconjugated
Gene
IRF3
Gene Alias
C920001K05Rik, IIAE7, Interferon regulatory factor 3, IRF3, IRF-3, IRF3 (phospho S386), IRF3 (pS386), IRF3 (pSer386), IRF3 phospho, IRF3 phospho S386, IRF3 phospho Ser386, phospho IRF3
Host Species
Rabbit
Purification Method
Protein G
Regulatory Status
RUO
Gene ID (Entrez)
3661
Content And Storage
-20°C or -80°C if preferred
Form
Liquid
Related Products
Description
- IFR3 (interferon regulatory factor 3) is a key transcriptional regulator of type I interferon (IFN)-dependent immune responses
- It plays a critical role in the innate immune response against DNA and RNA viruses
- IFR3 regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters
- It acts as a more potent activator of the IFN-beta gene than the IFN-alpha gene and plays a critical role in both the early and late phases of the IFNA/B gene induction
- IFR3 is found in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA, or toll-like receptor signaling
- It is phosphorylated by IKBKE and TBK1 kinases
- This induces a conformational change, leading to its dimerization and nuclear localization and association with CREB binding protein to form dsRNA-activated factor 1 (DRAF1), a complex which activates the transcription of the type I IFN and ISG genes
- Mutations in the gene can result in encephalopathy, acute, infection-induced, herpes-specific 7.