Factor XIII A Monoclonal Antibody (16D3), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA534954-Each-of-1 | In Stock | ₹ 47,481.50 |
PIMA534954 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
Factor XIII A
Classification
Monoclonal
Concentration
2 mg/mL
Formulation
PBS with 0.2% BSA, 50% glycerol and 0.05% sodium azide; pH 7.4
Gene Accession No.
P00488
Gene Symbols
F13A1
Immunogen
Recombinant protein within Human F13A1 aa 259-463
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG1
Applications
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Clone
16D3
Conjugate
Unconjugated
Gene
F13A1
Gene Alias
1200014I03Rik; AI462306; bA525O21.1 (coagulation factor XIII, A1 polypeptide); coagulation factor XIII A chain; coagulation factor XIII, A polypeptide; coagulation factor XIII, A1 polypeptide; coagulation factor XIII, A1 subunit; coagulation factor XIII, alpha subunit; coagulation factor XIIIa; F13A; F13a1; factor viiia; Factor XIIIA; fibrin stabilizing factor, A subunit; fibrinoligase; FSF, A subunit; protein-glutamine gamma-glutamyltransferase A chain; RP11-232H4.1; TGase; transglutaminase A chain; transglutaminase. plasma
Host Species
Mouse
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
2162
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles, store in dark
Form
Liquid
Related Products
Description
- Positive Control: Human placenta tissue lysates, human placenta tissue, A549
- This gene encodes the coagulation factor XIII A subunit
- Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade
- Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits
- The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules
- Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin
- Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII
- This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot
- It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin
- Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone
- These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion.