Protein C Recombinant Rabbit Monoclonal Antibody (JM93-61), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA532737-Each-of-1 | In Stock | ₹ 46,413.50 |
PIMA532737 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,413.50
GST (18%): ₹ 8,354.43
Total Price: ₹ 54,767.93
Antigen
Protein C
Classification
Monoclonal
Concentration
1 mg/mL
Formulation
TBS with 0.05% BSA, 40% Glycerol and 0.05% sodium azide, pH 7.4
Gene Accession No.
P04070
Gene Symbols
PROC
Immunogen
Recombinant protein within Human Protein C aa 290-380
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot, Western Blot
Clone
JM93-61
Conjugate
Unconjugated
Gene
PROC
Gene Alias
Activation peptide, Anticoagulant protein C, APC, autoprothrombin IIA, Blood coagulation factor XIV, EDQVDPRLIDGK, inactivator of coagulation factors Va, VIII, PC, prepro-protein C, Proc, PROC1, protein C, protein C (inactivator of coagulation factors Va and VIIIa), protein C prepropeptide, protein C, inactivator of coagulation factors Va and VIIIa, THPH3, THPH4, type I protein C, vitamin K-dependent protein C, Vitamin K-dependent protein C heavy chain, Vitamin K-dependent protein C light chain
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
5624
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recombinant rabbit monoclonal antibodies are produced using in vitro expression systems
- The expression systems are developed by cloning in the specific antibody DNA sequences from immunoreactive rabbits
- Then, individual clones are screened to select the best candidates for production
- The advantages of using recombinant rabbit monoclonal antibodies include: better specificity and sensitivity, lot-to-lot consistency, animal origin-free formulations, and broader immunoreactivity to diverse targets due to larger rabbit immune repertoire
- Protein C is a vitamin K-dependent plasma glycoprotein that is cleaved to its activated form by the thrombin-thrombomodulin complex
- Protein C in its activated form contains a serine protease domain and functions in degradation of the activated forms of coagulation factors V and VIII
- Protein C is a vitamin K-dependent serine protease produced in the liver and made up of 2 polypeptide chains
- The 62 kDa proenzyme is activated by thrombin bound to an endothelial surface receptor and the active enzyme cleaves factor Va and VIIIa and thus inhibits blood coagulation
- The molecular weight of the active enzyme is 55 kDa and the normal concentrations in human plasma is approximately 1-3 ng/mL because of the very fast turnover, the proenzyme concentration is approximately 3 μg/mL
- Mutations in the Protein C gene have been associated with thrombophilia due to protein C deficiency, neonatal purpura fulminans, and recurrent venous thrombosis.