CD63 Recombinant Rabbit Monoclonal Antibody (2H5I1), Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIMA535208-Each-of-1 | In Stock | ₹ 46,947.50 |
PIMA535208 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,947.50
GST (18%): ₹ 8,450.55
Total Price: ₹ 55,398.05
Antigen
CD63
Classification
Monoclonal
Concentration
0.46 mg/mL
Formulation
PBS with 0.05% BSA, 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.
P08962, P28648, P41731
Gene Symbols
CD63
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 103-203 of human CD63 (NP_0017711)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
2H5I1
Conjugate
Unconjugated
Gene
CD63
Gene Alias
C75951; CD 63; Cd63; CD63 antigen; CD63 antigen (melanoma 1 antigen); Cd63 molecule; CD63 protein; granulophysin; LAMP-3; Lysosomal-associated membrane protein 3; lysosome-associated membrane glycoprotein 3; mast cell antigen AD1; ME491; melanoma 1 antigen; melanoma-associated antigen ME491; melanoma-associated antigen MLA1; MLA1; Ocular melanoma-associated antigen; OMA81H; Tetraspanin-30; TSPAN30; tspan-30
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12512, 29186, 967
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Related Products
Description
- Immunogen sequence: AGYVFRDKVM SEFNNNFRQQ MENYPKNNHT ASILDRMQAD FKCCGAANYT DWEKIPSMSK NRVPDSCCIN VTVGCGINFN EKAIHKEGCV EKIGGWLRKN V CD63 (LAMP-3, lysosome-associated membrane protein-3), a glycoprotein of tetraspanin family, is present in late endosomes, lysosomes and secretory vesicles of various cell types
- CD63 is also present in the plasma membrane, usually following cell activation
- Hence, CD63 has become a widely used basophil activation marker
- In mast cells, however, CD63 exposition does not need their activation
- CD63 interacts with integrins and affects phagocytosis and cell migration, it is also involved in H/K-ATPase trafficking regulation of ROMK1 channels
- CD63 also serves as a T-cell costimulation molecule
- Expression of CD63 can be used for predicting the prognosis in earlier stages of carcinomas
- CD63 is expressed on activated platelets, and is a lysosomal membrane glycoprotein that is translocated to plasma membrane after platelet activation
- CD63 is also present in monocytes and macrophages and is weakly expressed on granulocytes, B, and T cells
- CD63 is identical to the melanoma-associated antigen which is ME491 and to the platelet antigen PTLGP40
- Diseases associated with CD63 dysfunction include melanoma and Hermansky-Pudlak Syndrome.