PIPA121354
IL-21 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA121354-Each-of-1 | In Stock | ₹ 52,777.00 |
PIPA121354 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,777.00
GST (18%): ₹ 9,499.86
Total Price: ₹ 62,276.86
Antigen
IL-21
Classification
Polyclonal
Conjugate
Unconjugated
Gene
IL21
Gene Alias
CVID11; CX2; il 21; IL21; IL-21; ILN; Interleukin; interleukin 21; Interleukin21; interleukin-21; interleukin-21 isoform; porcine interleukin-21; Za11
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
59067
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ELISA
Concentration
1 mg/mL
Formulation
0.01M potassium phosphate with 0.14M NaCl, 1mg/mL BSA and 0.1% sodium azide
Gene Accession No.
Q9HBE4
Gene Symbols
IL21
Immunogen
Synthetic peptide of Human IL21 C terminal amino acids 118-146 [CDSYEKKPPKEFLERFKSLLQKMIHQHLS]
Quantity
50 μg
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: Human spleen cells
- IL-21 is a 17 kDa immunomodulatory cytokine produced mainly by Natural Killer Cells (NKT), T helper (Th) 17 and T follicular helper (TFH) cells
- In TFH cells, IL-21 expression leads to autocrine signaling through the IL-21 receptor (IL-21R) and STAT3, which leads to additional transcriptional activation by Bcl6
- As with IFN gamma for Th1 and IL-4 for Th2 cells, IL-21 is critical for TFH cell development and effector function
- IL-21 plays a role in T cell-dependent B cell differentiation into plasma cells and memory cells, stimulation of IgG production and induction of apoptotic signaling in naive B cells
- In Th17 cells, IL-21 expression and autocrine feedback through STAT3, IRF4 and ROR gamma t lead to upregulation of the IL-23R, thereby preparing Th17 cells for maturation and maintenance by the inflammatory cytokine IL-23
- While upregulating IRF4 and ROR gamma t, IL-21 also mediates the downregulation of Foxp3
- IL-21 deficient mice are protected from developing colitis upon chemical treatment by their inability to upregulate Th17-associated molecules
- In comparison, elevated levels of IL-21 are present in chemically-induced colitis mouse models.