PIPA122494
IL-15 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA122494-Each-of-1 | In Stock | ₹ 47,481.50 |
PIPA122494 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,481.50
GST (18%): ₹ 8,546.67
Total Price: ₹ 56,028.17
Antigen
IL-15
Classification
Polyclonal
Conjugate
Unconjugated
Gene
IL15
Gene Alias
AI503618; il 15; Il15; IL-15; ILN; Interleukin; interleukin 15; Interleukin15; interleukin-15; MGC9721; M-IL-15
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
16168
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Neutralization, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 0.1% sodium azide
Gene Accession No.
P48346
Gene Symbols
IL15
Immunogen
Recombinant full length protein (Mouse). Expressed in E. coli
Quantity
25 μg
Primary or Secondary
Primary
Target Species
Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- PA1-22494 detects IL-15 in Mouse samples
- IL-15 (Interleukin 15 ) is a cytokine that regulates T and natural killer cell activation and proliferation
- IL-15 and IL-2 share many biological activities as both have been found to bind common hematopoietin receptor subunits, and may compete for the same receptor, and thus negatively regulate each other's activity
- The number of CD8+ memory cells is shown to be controlled by a balance between IL-15 and IL-2
- IL-15 induces the activation of JAK kinases, as well as the phosphorylation and activation of transcription activators STAT3, STAT5, and STAT6
- In mouse, studies suggest that IL-15 may increase the expression of apoptosis inhibitor Bcl-xL, possibly through the transcription activation activity of STAT6, and thus prevent apoptosis
- IL-15 plays an important role in the growth and differentiation of T and B lymphocytes, natural killer cells, macrophages, and monocytes as well as activation of a number of important intracellular signaling molecules
- As such, IL-15 could be essential for the immune responses, allograft rejection, and the pathogenesis of autoimmune diseases
- Further, IL-15 is a widely expressed pro-inflammatory cytokine and has been shown to play a role in several inflammatory disorders, including rheumatoid arthritis, psoriasis and pulmonary inflammatory diseases
- Emerging data suggest that IL-15 may serve as a good therapeutic target, as there appears to be a beneficial effect of IL-15 neutralization in models of psoriasis and diabetes.