Catenin alpha-1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA125081-Each-of-1 | In Stock | ₹ 49,261.50 |
PIPA125081 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 49,261.50
GST (18%): ₹ 8,867.07
Total Price: ₹ 58,128.57
Antigen
Catenin alpha-1
Classification
Polyclonal
Formulation
0.01M PBS with 15mM sodium azide; pH 7.4
Gene Accession No.
P26231, P35221
Gene Symbols
CTNNA1, ctnna1.S
Immunogen
Synthetic peptide, conjugated to KLH, corresponding to residues E(873) K Q D E T Q T K I K R A S Q(887) of human alpha 1 Catenin.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Canine, Human, Mouse, Rat, X. laevis
Product Type
Antibody
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Conjugate
Unconjugated
Gene
CTNNA1
Gene Alias
[a]E-catenin; 102 kDa cadherin-associated protein; 2010010M04Rik; AA517462; AI988031; alpha E catenin; alpha E-catenin; alpha(E)-catenin; alpha-E-catenin; cadherin associated protein; Cadherin-associated protein; CAP102; catenin (cadherin associated protein), alpha 1; catenin (cadherin-associated protein), alpha; catenin (cadherin-associated protein), alpha 1; catenin (cadherin-associated protein), alpha 1, 102kDa; catenin alpha 1; catenin alpha 1 S homeolog; catenin alpha-1; catenin, alpha 1; Catna1; cell-adhesion protein alphaE catenin; ctnna; ctnna1; ctnna1.S; MDPT2; Renal carcinoma antigen NY-REN-13; XELAEV_18020018mg
Host Species
Rabbit
Purification Method
IgG fraction
Regulatory Status
RUO
Gene ID (Entrez)
12385, 1495, 307505, 399303, 474698
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- Recommended positive controls: A431 and cytosolic fraction of rat embryonic brain, MDCK, MCF-7
- PA1-25081 is expected to cross react with mouse (100% conserved) and Xenopus laevis (100% conserved) due to sequence homology
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- Associates with the cytoplasmic domain of a variety of cadherins
- The association of catenins to cadherins produces a complex which is linked to the actin filament network, and which seems to be of primary importance for cadherins cell-adhesion properties
- Can associate with both E- and N-cadherins
- Originally believed to be a stable component of E-cadherin/catenin adhesion complexes and to mediate the linkage of cadherins to the actin cytoskeleton at adherens junctions
- In contrast, cortical actin was found to be much more dynamic than E-cadherin/catenin complexes and CTNNA1 was shown not to bind to F-actin when assembled in the complex suggesting a different linkage between actin and adherence junctions components
- The homodimeric form may regulate actin filament assembly and inhibit actin branching by competing with the Arp2/3 complex for binding to actin filaments
- May play a crucial role in cell differentiation.