p130 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA126037-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA126037 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
p130
Classification
Polyclonal
Conjugate
Unconjugated
Gene
RBL2
Gene Alias
130 kDa retinoblastoma-associated protein; FLJ26459; p130; PPAR-alpha-interacting complex protein 128; PRB2; PRIC128; RB transcriptional corepressor like 2; Rb2; rb2 p130; Rbl2; RBR-2; retinoblastoma-like 2; retinoblastoma-like 2 (p130); retinoblastoma-like protein 2; Retinoblastoma-related protein 2
Host Species
Rabbit
Purification Method
Protein A
Regulatory Status
RUO
Gene ID (Entrez)
19651, 5934, 81758
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry (Frozen), Immunohistochemistry (PFA fixed), Immunoprecipitation, Western Blot
Concentration
0.2 mg/mL
Formulation
PBS with 0.2% gelatin and 0.1% sodium azide
Gene Accession No.
O55081, Q08999, Q64700
Gene Symbols
RBL2
Immunogen
Synthetic peptide corresponding to the C-terminal region of human Rb2 p130.
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Description PA1-26037 detects Rb2 p130 from human, mouse, and rat samples
- RBL2 (also known as p130) or Retinoblastoma-like protein 2 is a key regulator of entry into cell division
- It is directly involved in heterochromatin formation by maintaining overall chromatin structure and (in particular) that of constitutive heterochromatin by stabilizing histone methylation
- RBL2 recruits and targets histone methyltransferases KMT5B and KMT5C leading to epigenetic transcriptional repression
- It controls histone H4 'Lys20' trimethylation
- It probably also acts as a transcription repressor by recruiting chromatin-modifying enzymes to promoters
- RBL2 serves as a potent inhibitor of E2F-mediated trans-activation and associates preferentially with E2F5.