SIGIRR Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA129825-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA129825 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
SIGIRR
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SIGIRR
Gene Alias
AI256711; IL-1R8; MGC110992; Sigirr; single Ig and TIR domain containing; single Ig IL-1 receptor related protein; single Ig IL-1-related receptor; Single Ig IL-1R-related molecule; single Ig IL-1R-related protein; single immunoglobulin and toll-interleukin 1 receptor (TIR) domain; single immunoglobulin domain IL1R1 related; single immunoglobulin domain-containing IL1R-related protein; TIR8; Toll/interleukin-1 receptor 8; UNQ301/PRO342
Host Species
Rabbit
Quantity
200 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Applications
Western Blot
Concentration
Conc. Not Determined
Formulation
whole serum diluted in PBS with 0.1mg/mL BSA and 0.02% sodium azide
Gene Accession No.
Q6IA17
Gene Symbols
SIGIRR
Immunogen
Synthetic peptides corresponding to aa 309-323 and 380-393 of human SIGIRR.
Regulatory Status
RUO
Gene ID (Entrez)
59307
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Related Products
Description
- PA1-29825 detects SIGIRR from human samples
- SIGIRR (single Ig IL-1R-related molecule) is a novel member of the interleukin 1 receptor (IL-1R) superfamily
- Although it shows the typical conserved motifs that characterize the IL-1R and Toll superfamily, it is structurally and functionally distinct from both
- SIGIRR has only one Ig domain in its extracellular portion whereas the IL-1R family contains three Ig folds
- An unusually long cytoplasmic domain is reminiscent of the structure of drosophila Toll, yet the SIGIRR peptide sequence is more closely related to IL-1RI
- A chimera, in which the SIGIRR intracellular domain was fused to the IL-1R extracellular domain, did not activate NFkappaB unlike similar fusion proteins of other IL-1R related molecules
- Phylogenetic data that suggest that the plasma membrane protein SIGIRR is a close functional relative of MyD88 in mammals.