CHP2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5101475-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5101475 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
CHP2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CHP2
Gene Alias
2010110P09Rik; calcineurin B homologous protein 2; calcineurin like EF-hand protein 2; calcineurin-like EF hand protein 2; calcineurin-like EF-hand protein 2; Cbhp2; CHP2; chp-2; HCA520; hepatocellular carcinoma antigen gene 520; hepatocellular carcinoma-associated antigen 520; Hepatocellular carcinoma-associated antigen 520 homolog
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
308965, 63928, 70261
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
O43745, Q810D1, Q9D869
Gene Symbols
CHP2
Immunogen
A synthesized peptide derived from human CHP2(Accession O43745), corresponding to amino acid residues P103-L153.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total CHP2
- CHP2 (Calcineurin B homologous protein 2), also known as Hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains four EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange
- By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death
- Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen
- Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation
- Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.