LYAR Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5101505-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5101505 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
LYAR
Classification
Polyclonal
Conjugate
Unconjugated
Gene
LYAR
Gene Alias
apoptosis-related protein; cell growth-regulating nucleolar protein; hypothetical protein FLJ20425; Ly1 antibody reactive; Ly1 antibody reactive clone; Ly1 antibody reactive homolog; Ly1 antibody-reactive protein; Lyar; LYAR protein; MLZ-264; PNAS-5; protein expressed in male leptotene and zygotene spermatocytes 264; ZC2HC2; ZLYAR
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
17089, 55646
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q08288, Q9NX58
Gene Symbols
LYAR
Immunogen
A synthesized peptide derived from human LYAR(Accession Q9NX58), corresponding to amino acid residues K250-D300.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total LYAR
- Plays a role in the maintenance of the appropriate processing of 47S/45S pre-rRNA to 32S/30S pre-rRNAs and their subsequent processing to produce 18S and 28S rRNAs (PubMed:24495227)
- Also acts at the level of transcription regulation
- Along with PRMT5, binds the gamma-globin (HBG1/HBG2) promoter and represses its expression (PubMed:25092918)
- In neuroblastoma cells, may also repress the expression of oxidative stress genes, including CHAC1, HMOX1, SLC7A11, ULBP1 and SNORD41 that encodes a small nucleolar RNA (PubMed:28686580)
- Preferentially binds to a DNA motif containing 5'-GGTTAT-3' (PubMed:25092918)
- Negatively regulates the antiviral innate immune response by targeting IRF3 and impairing its DNA-binding activity (PubMed:31413131)
- In addition, inhibits NF-kappa-B-mediated expression of proinflammatory cytokines (PubMed:31413131)
- Stimulates phagocytosis of photoreceptor outer segments by retinal pigment epithelial cells
- Prevents nucleolin/NCL self-cleavage, maintaining a normal steady-state level of NCL protein in undifferentiated embryonic stem cells (ESCs), which in turn is essential for ESC self-renewal
- [UniProt]