DKC1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5102502-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5102502 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
DKC1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
DKC1
Gene Alias
BC068171; CBF5; CBF5 homolog; DKC; DKC1; DKCX; dyskeratosis congenita 1, dyskerin; dyskeratosis congenita 1, dyskerin homolog; dyskerin; dyskerin pseudouridine synthase 1; H/ACA ribonucleoprotein complex subunit 4; H/ACA ribonucleoprotein complex subunit DKC1; Nap57; NOLA4; Nopp140-associated protein of 57 kDa; nucleolar protein family A member 4; Nucleolar protein NAP57; snoRNP protein DKC1; XAP101
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
170944, 1736, 245474
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
O60832, P40615, Q9ESX5
Gene Symbols
DKC1
Immunogen
A synthesized peptide derived from human DKC1(Accession O60832), corresponding to amino acid residues R183-L233.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total DKC1
- This gene is a member of the H/ACA snoRNPs gene family
- snoRNPs are involved in various aspects of rRNA processing and modification and have been classified into two families: C/D and H/ACA
- The H/ACA snoRNPs also include the NOLA1, 2 and 3 proteins
- The protein encoded by this gene and the three NOLA proteins localize to the dense fibrillar components of nucleoli and to coiled bodies in the nucleus
- Both 18S rRNA production and rRNA pseudouridylation are impaired if any one of the four proteins is depleted
- These four H/ACA snoRNP proteins are also components of the telomerase complex
- The protein encoded by this gene is related to the Saccharomyces cerevisiae Cbf5p and Drosophila melanogaster Nop60B proteins
- The gene lies in a tail-to-tail orientation with the palmitoylated erythrocyte membrane protein gene and is transcribed in a telomere to centromere direction
- Both nucleotide substitutions and single trinucleotide repeat polymorphisms have been found in this gene
- Mutations in this gene cause X-linked dyskeratosis congenita, a disease resulting in reticulate skin pigmentation, mucosal leukoplakia, nail dystrophy, and progressive bone marrow failure in most cases
- Mutations in this gene also cause Hoyeraal-Hreidarsson syndrome, which is a more severe form of dyskeratosis congenita
- Two transcript variants encoding different isoforms have been found for this gene.