RMP Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5103250-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5103250 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
RMP
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Uri1
Gene Alias
C19orf2; C80913; FLJ10575; Nnx3; Ppp1r19; Protein NNX3; Protein phosphatase 1 regulatory subunit 19; protein phosphatase 1, regulatory subunit 19; RMP; RNA polymerase II subunit 5-mediating protein; RPB5-mediating protein; Unconventional prefoldin RPB5 interactor; unconventional prefoldin RPB5 interactor 1; URI; Uri1; URI1 prefoldin-like chaperone; URI1, prefoldin like chaperone; URI1, prefoldin-like chaperone
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
19777, 8725
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
O94763, Q3TLD5
Gene Symbols
Uri1
Immunogen
A synthesized peptide derived from human URI1(Accession O94763), corresponding to amino acid residues R393-C443.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total RMP
- Involved in gene transcription regulation
- Acts as a transcriptional repressor in concert with the corepressor UXT to regulate androgen receptor (AR) transcription
- May act as a tumor suppressor to repress AR-mediated gene transcription and to inhibit anchorage-independent growth in prostate cancer cells
- Required for cell survival in ovarian cancer cells
- Together with UXT, associates with chromatin to the NKX3-1 promoter region
- Antagonizes transcriptional modulation via hepatitis B virus X protein
- Plays a central role in maintaining S6K1 signaling and BAD phosphorylation under normal growth conditions thereby protecting cells from potential deleterious effects of sustained S6K1 signaling
- The URI1-PPP1CC complex acts as a central component of a negative feedback mechanism that counteracts excessive S6K1 survival signaling to BAD in response to growth factors
- Mediates inhibition of PPP1CC phosphatase activity in mitochondria
- Coordinates the regulation of nutrient-sensitive gene expression availability in a mTOR-dependent manner
- Seems to be a scaffolding protein able to assemble a prefoldin-like complex that contains PFDs and proteins with roles in transcription and ubiquitination
- [Uniprot]