PRKAR2B Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5102922-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5102922 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
PRKAR2B
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Prkar2b
Gene Alias
AI451071; AW061005; cAMP-dependent protein kinase RII-beta regulatory subunit; cAMP-dependent protein kinase type II-beta regulatory chain; cAMP-dependent protein kinase type II-beta regulatory subunit; H_RG363E19.2; Pkarb2; PKARIIbeta; PRKAR2; PRKAR2B; protein kinase cAMP-dependent type II regulatory subunit beta; protein kinase, cAMP dependent regulatory, type II beta; protein kinase, cAMP-dependent, regulatory subunit type II beta; protein kinase, cAMP-dependent, regulatory, type II, beta; RATDNA; RII(beta); RII-BETA; Type II beta regulatory subunit of cAMP-dependent protein kinase; WUGSC:H_RG363E19.2
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
19088, 24679, 5577
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P12369, P31323, P31324
Gene Symbols
Prkar2b
Immunogen
A synthesized peptide derived from human PRKAR2B(Accession P31323), corresponding to amino acid residues E91-Q141.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total PKA-R2 beta
- cAMP is a signaling molecule important for a variety of cellular functions
- cAMP exerts its effects by activating the cAMP-dependent protein kinase, which transduces the signal through phosphorylation of different target proteins
- The inactive kinase holoenzyme is a tetramer composed of two regulatory and two catalytic subunits
- cAMP causes the dissociation of the inactive holoenzyme into a dimer of regulatory subunits bound to four cAMP and two free monomeric catalytic subunits
- Four different regulatory subunits and three catalytic subunits have been identified in humans
- The protein encoded by this gene is one of the regulatory subunits
- This subunit can be phosphorylated by the activated catalytic subunit
- This subunit has been shown to interact with and suppress the transcriptional activity of the cAMP responsive element binding protein 1 (CREB1) in activated T cells
- Knockout studies in mice suggest that this subunit may play an important role in regulating energy balance and adiposity
- The studies also suggest that this subunit may mediate the gene induction and cataleptic behavior induced by haloperidol.