HLA-DMA Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5103886-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5103886 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
HLA-DMA
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HLA-DMA
Gene Alias
class II histocompatibility antigen, M alpha chain; D6S222E; DAAP-27A1.5; DMA; HLA class II histocompatibility antigen, DM alpha chain; HLADM; HLA-DMA; major histocompatibility complex, class II, DM alpha; MHC class II antigen DMA; really interesting new gene 6 protein; RING6
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
3108
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
P28067
Gene Symbols
HLA-DMA
Immunogen
A synthesized peptide derived from human HLA-DMA(Accession P28067), corresponding to amino acid residues M34-E84.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total HLA-DMA
- HLA-DMA belongs to the HLA class II alpha chain paralogues
- This class II molecule is a heterodimer consisting of an alpha (DMA) and a beta chain (DMB), both anchored in the membrane
- It is located in intracellular vesicles
- DM plays a central role in the peptide loading of MHC class II molecules by helping to release the CLIP molecule from the peptide binding site
- Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages)
- The alpha chain is approximately 33-35 kDa and its gene contains 5 exons
- Exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and the cytoplasmic tail
- HLA and MHC antibodies play a significant role in Immunopeptidomics, facilitating the identification and characterization of neoantigens through high-performance liquid chromatography coupled to tandem Mass Spectrometry.