Phospho-BAP1 (Ser592) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5104574-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5104574 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-BAP1 (Ser592)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
BAP1
Gene Alias
2300006C11Rik; AA989761; AW553466; BAP1; Brca1 associated protein 1; BRCA1 associated protein-1 (ubiquitin carboxy-terminal hydrolase); BRCA1-associated protein 1; Cerebral protein 6; cerebral protein-13; DKFZp686N04275; FLJ35406; FLJ37180; HUCEP-13; hucep-6; KIAA0272; mKIAA0272; Ubiquitin carboxyl-terminal hydrolase BAP1; ubiquitin C-terminal hydrolase X4; UCHL2; uch-x4
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
104416, 8314
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q92560, Q99PU7
Gene Symbols
BAP1
Immunogen
A synthesized peptide derived from human BAP1(Accession Q92560), corresponding to amino acid residues around phosphorylated Ser592.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of BAP1 only when phosphorylated at Ser592
- BRCA1-associated protein-1, or BAP1, interacts with the RING finger domain of BRCA1
- The N-terminal 240 amino acids of the predicted 729-amino acid human protein show homology to ubiquitin C-terminal hydrolases (UCHs), thiol proteases that catalyze proteolytic processing of ubiquitin
- In addition, BAP1 contains an acidic region, a highly charged C-terminal region, and 2 putative nuclear localization signals
- BAP1 and BRCA1 associate in vivo and have overlapping subnuclear localization patterns
- BAP1 enhances BRCA1-mediated inhibition of breast cancer cell growth
- Northern blot analysis indicates that BAP1 is expressed as a 4-kb mRNA in all human tissues tested, with A 4
- 8-kb transcript expressed exclusively in testis
- Northern blot analysis and in situ hybridization reveal that BAP1 and BRCA1 are coexpressed during murine breast development and remodeling
- The BAP1 gene has been mapped to 3p21
- 3, a region of loss of heterozygosity for breast cancer as well as frequently deleted in lung carcinomas
- Intragenic homozygous rearrangements and deletions of BAP1 appear in lung carcinoma cell lines
- It has been postulated that BAP1 is a tumor suppressor gene that functions in the BRCA1 growth control pathway.