Phospho-SKP2 (Ser64) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5104654-Each-of-1 | In Stock | ₹ 45,345.50 |
PIPA5104654 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,345.50
GST (18%): ₹ 8,162.19
Total Price: ₹ 53,507.69
Antigen
Phospho-SKP2 (Ser64)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SKP2
Gene Alias
4930500A04Rik; CDK2/cyclin A-associated protein p45; cyclin A/CDK2-associated protein p45; Cyclin-A/CDK2-associated protein p45; FBL1; F-box protein Skp2; F-box/LRR-repeat protein 1; F-box/WD-40 protein 1; FBXL1; FLB1; FWD1; MGC1366; OTTHUMP00000221389; p45; p45skp2; RGD1562456; Skp2; S-phase kinase-associated protein 2; S-phase kinase-associated protein 2 (p45); S-phase kinase-associated protein 2, E3 ubiquitin protein ligase
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
27401, 294790, 6502
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q13309, Q9Z0Z3
Gene Symbols
SKP2
Immunogen
A synthesized peptide derived from human SKP2(Accession Q13309), corresponding to amino acid residues around phosphorylated Ser64.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of SKP2/p45 only when phosphorylated at Ser64
- Skp2 (S-phase Kinase-associated Protein 2) belongs to the family of F-box proteins that interact with the Cyclin A-Cdk2 complex
- Skp2 is essential for the G1-S transition in both transformed cells and diploid fibroblasts
- Biochemical and genetic experiments have demonstrated that Skp2 is required for the ubiquitination and consequent degradation of p27 in cultured mammalian cells and in vitro reconstitution assays
- In normal tissues, Skp2 is expressed in tonsil and placenta
- In tumor tissues, Skp2 is expressed widely, in some colon, prostate, pancreas, and skin cancers, with high expression in lung, breast, ovarian, and endometrial cancers
- Research suggests that Skp2 plays a role in oncogenesis, particularly in the pathogenesis of lymphomas and breast cancers.