Phospho-Elk1 (Ser383) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5104832-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5104832 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-Elk1 (Ser383)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ELK1
Gene Alias
ELK 1; ELK1; Elk-1; ELK1, ETS transcription factor; ELK1, member of ETS oncogene family; ETS domain-containing protein Elk-1; ETS transcription factor ELK1; ETS-like gene 1; Oncogene Elk1; tyrosine kinase (ELK1) oncogene
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
13712, 2002, 314436
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
A4GTP4, P19419, P41969
Gene Symbols
ELK1
Immunogen
A synthesized peptide derived from human ELK1(Accession P19419), corresponding to amino acid residues around phosphorylated Ser383.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Non-human Primate, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of ELK1 only when phosphorylated at Serine 383
- ELK1 is a component of the ternary complex that binds the serum response element (SRE) and mediates gene activity in response to serum and growth factors
- ELK1 is phosphorylated by MAP kinase pathways at a cluster of S/T motifs at its C-terminus
- Phosphorylation at these sites, particularly Ser383, is critical for transcriptional activation by ELK1
- ELK1 appears to be a direct target of activated MAP kinase
- Biochemical studies indicate that ELK1 is a good substrate for MAP kinase, the kinetics of ELK1 phosphorylation and activation correlate with MAP kinase activity, and interfering mutants of MAP kinase block ELK1 activation in vivo
- ELK1 is a nuclear target for the ras-raf-MAPK signaling cascade
- Alternatively spliced transcript variants encoding the same protein have been found for ELK1.