PIPA5105092
Phospho-KSR1 (Thr425) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5105092-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5105092 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Phospho-KSR1 (Thr425)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
KSR1
Gene Alias
AW492498; B-KSR1; CAP kinase; D11Bhm183e; D11Bhm184e; hb; HB protein; kinase KSR1; Kinase suppressor of Ras 1; Ksr; KSR1; mKSR1; OTTHUMP00000162931; protein Hb; RSU2
Host Species
Rabbit
Purification Method
sequential chromatography
Regulatory Status
RUO
Gene ID (Entrez)
16706, 360573, 8844
Content And Storage
-20°C
Form
Liquid
Applications
Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
Q61097, Q8IVT5
Gene Symbols
KSR1
Immunogen
A synthesized peptide derived from human KSR1(Accession Q8IVT5), corresponding to amino acid residues around phosphorylated Thr425.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of KSR1 only when phosphorylated at Thr425
- Part of a multiprotein signaling complex which promotes phosphorylation of Raf family members and activation of downstream MAP kinases
- Independently of its kinase activity, acts as MAP2K1/MEK1 and MAP2K2/MEK2-dependent allosteric activator of BRAF; upon binding to MAP2K1/MEK1 or MAP2K2/MEK2, dimerizes with BRAF and promotes BRAF-mediated phosphorylation of MAP2K1/MEK1 and/or MAP2K2/MEK2 (PubMed:29433126)
- Promotes activation of MAPK1 and/or MAPK3, both in response to EGF and to cAMP
- Its kinase activity is unsure
- Some protein kinase activity has been detected in vitro, however the physiological relevance of this activity is unknown
- [UniProt]