SIAH2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5105291-Each-of-1 | In Stock | ₹ 47,392.50 |
PIPA5105291 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,392.50
GST (18%): ₹ 8,530.65
Total Price: ₹ 55,923.15
Antigen
SIAH2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SIAH2
Gene Alias
AA415433; E3 ubiquitin-protein ligase SIAH2; EC 6.3.2; hSiah2; mSiah2; RING-type E3 ubiquitin transferase SIAH2; seven in absentia 2; seven in absentia homolog 2; siah E3 ubiquitin protein ligase 2; SIAH2; siah-2; Sinh2
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
140593, 20439, 6478
Content And Storage
-20°C
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.4
Gene Accession No.
O43255, Q06986, Q8R4T2
Gene Symbols
SIAH2
Immunogen
A synthesized peptide derived from human SIAH2(Accession O43255), corresponding to amino acid residues F246-C296.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Antibody detects endogenous levels of total SIAH2
- SIAH-2 (seven in absentia homolog 2) is an E3 ligase that catalyzes ubiquitination and proteasome-mediated degradation of protein substrates
- SIAH-2 encodes a 324 amino acid protein that shares 77% identity with human SIAH-1 and 68% identity with the Drosophila sina (seven in absentia) gene, on which development of the Drosophila R7 photoreceptor is dependent
- SIAH-2 targets TRAF2 (which regulates cell responses to stress and cytokines through the regulation of key stress-signaling cascades) for degradation under stress conditions such as hypoxia
- It targets HIF-1 alpha prolyl hydroxylase 3 (PHD3) for degradation upon exposure to hypoxic conditions, which coincides with an increase in SIAH-2 transcription
- SIAH-2 can decrease TNF-alpha-dependent induction of JNK activity and transcriptional activation of NFkB
- SIAH-2 null mice subjected to hypoxia display an impaired respiratory response and reduced levels of hemoglobin.