SPIN2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5113319-Each-of-1 | In Stock | ₹ 43,120.50 |
PIPA5113319 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 43,120.50
GST (18%): ₹ 7,761.69
Total Price: ₹ 50,882.19
Antigen
SPIN2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
SPIN2B
Gene Alias
BC068162; dJ323P24.2; Spin2; SPIN-2; SPIN2_duplicate; SPIN2B; SPIN-2B; Spin2c; SPIN-2C; Spindlin 2B; spindlin family member 2B; spindlin family, member 2; spindlin family, member 2 duplicate; spindlin family, member 2B; spindlin family, member 2C; spindlin-2; spindlin-2B; Spindlin-2C; spindlin-like protein 2; spindlin-like protein 2B; Spindlin-like protein 2C; TDRD26; telomeric SPIN2 copy
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
278240, 474343
Content And Storage
-20°C or -80°C if preferred
Form
Liquid
Applications
ELISA, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.48 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide; pH 7.3
Gene Accession No.
Q6NVE3, Q9BPZ2
Gene Symbols
SPIN2B, Spin2c
Immunogen
Recombinant Human Spindlin-2B protein (1-258AA)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Human SPIN2 expressed by 2 IL3-dependent murine myeloid cell lines was moderately antiapoptotic following IL3 removal, but it was unable to block apoptosis induced by the chemotherapy agent doxorubicin
- On the contrary, SPIN2-expressing cells were more sensitive to doxorubicin-mediated cell death
- Also, SPIN2 did not combat the proapoptotic effects of Fas ligand stimulation in the Jurkat human T-cell line
- Deletion of the C-terminal amino acids of SPIN2 diminished its antiapoptotic activity
- In the murine myeloid cells, SPIN2 overexpression increased the cell number doubling times and slowed their rate of growth
- There was also an increased percentage of cells in G2/M, which was more pronounced following IL3 withdrawal.