HTRA1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA511412-Each-of-1 | In Stock | ₹ 48,816.50 |
PIPA511412 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,816.50
GST (18%): ₹ 8,786.97
Total Price: ₹ 57,603.47
Antigen
HTRA1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HTRA1
Gene Alias
AI429470; ARMD7; CADASIL2; CARASIL; High-temperature requirement A serine peptidase 1; HTRA; HtrA serine peptidase 1; Htra1; IGF binding; IGFBP5-protease; insulin-like growth factor binding protein 5 protease; L56; ORF480; protease serine 11; protease, serine, 11; protease, serine, 11 (IGF binding); PRSS11; RSPP11; serine protease; serine protease 11; Serine protease HTRA1; similar to bacterial htrA and degP
Host Species
Rabbit
Purification Method
Ammonium sulfate precipitation, Size-exclusion - Dialysis
Regulatory Status
RUO
Gene ID (Entrez)
56213, 5654
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
Q92743, Q9R118
Gene Symbols
HTRA1
Immunogen
KLH conjugated synthetic peptide between 116-147 amino acids from the N-terminal region of human HtrA1
Quantity
200 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- HtrA1, a 51KDa protein, is a member of highly conserved mammalian HtrA serine protease family
- It is a human homolog of bacterial HtrA and consists of a secretory signal sequence, an IGFBP-binding domain and a Kazal-type serine-protease inhibitor domain at the N-terminus and a highly conserved trypsin-like serine/protease domain and a PDZ domain at the C-terminus
- It plays a major role in the regulation of cell growth
- HtrA1 inhibits signaling mediated by TGF-beta family members and regulates many physiological processes
- HtrA1 is up-regulated in placenta during pregnancy and plays an important role in implantation and placental physiology
- It regulates the availability of IGFs by cleaving IGF-binding proteins
- It acts as a tumor suppressor and is down-regulated in ovarian cancers and melanomas
- Its role has been implicated in osteoarthritis suggesting a therapeutic intervention
- Northern blot analysis detected high expression in placenta.