Adiponectin Receptor 2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5114166-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5114166 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Adiponectin Receptor 2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ADIPOR2
Gene Alias
1110001I14Rik; ACDCR2; ADCR2; adiponectin receptor 2; adiponectin receptor protein 2; Adipor2; AI115388; AW554121; D6Ucla1e; FLJ21432; MGC4640; Paqr2; Parq2; Progestin and adipoQ receptor family member 2; Progestin and adipoQ receptor family member II
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
79602
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 2% sucrose and 0.09% sodium azide
Gene Accession No.
Q86V24
Gene Symbols
ADIPOR2
Immunogen
Immunogen sequence: FPGKCDIWFH SHQLFHIFVV AGAFVHFHGV SNLQEFRFMI GGGCSEEDAL
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: FPGKCDIWFH SHQLFHIFVV AGAFVHFHGV SNLQEFRFMI GGGCSEEDAL For short term use, store at 2-8°C up to 1 week
- For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles
- Predicted homology: Cow: 93%; Dog: 93%; Goat: 92%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 93% Adiponectin (also known as 30-kDa adipocyte complement-related protein; Acrp30) is a hormone secreted by adipocytes that acts as an antidiabetic and anti-atherogenic adipokine
- Levels of adiponectin in the blood are decreased under conditions of obesity, insulin resistance and type 2 diabetes
- Administration of adiponectin causes glucose-lowering effects and ameliorates insulin resistance in mice
- Conversely, adiponectin-deficient mice exhibit insulin resistance and diabetes
- This insulin-sensitizing effect of adiponectin seems to be mediated by an increase in fatty-acid oxidation through activation of AMP kinase and PPAR
- Here we report the cloning of complementary DNAs encoding adiponectin receptors 1 and 2 (AdipoR1 and AdipoR2) by expression cloning
- AdipoR1 is abundantly expressed in skeletal muscle, whereas AdipoR2 is predominantly expressed in the liver
- These two adiponectin receptors are predicted to contain seven transmembrane domains, but are structurally and functionally distinct from G-protein-coupled receptors
- Expression of AdipoR1/R2 or suppression of AdipoR1/R2 expression by small-interfering RNA supports our conclusion that they serve as receptors for globular and full-length adiponectin, and that they mediate increased AMP kinase and PPAR- ligand activities, as well as fatty-acid oxidation and glucose uptake by adiponectin.