CMG2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5117052-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5117052 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
CMG2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ANTXR2
Gene Alias
2310046B19Rik; anthrax toxin receptor 2; ANTXR cell adhesion molecule 2; ANTXR cell adhesion molecule 2; anthrax toxin receptor 2; ANTXR2; AW561899; Capillary morphogenesis gene 2 protein; capillary morphogenesis protein 2; cI-35; CMG2; CMG-2; FLJ31074; HFS; ISH; JHF; MGC111533; MGC45856
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
118429, 305633, 71914
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.89 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
P58335, Q6DFX2
Gene Symbols
ANTXR2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 34-300 of human ANTXR2 (NP_0011392661)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: Mouse eye, Rat lung Immunogen sequence: QEQPSCRRAF DLYFVLDKSG SVANNWIEIY NFVQQLAERF VSPEMRLSFI VFSSQATIIL PLTGDRGKIS KGLEDLKRVS PVGETYIHEG LKLANEQIQK AGGLKTSSII IALTDGKLDG LVPSYAEKEA KISRSLGASV YCVGVLDFEQ AQLERIADSK EQVFPVKGGF QALKGIINSI LAQSCTEILE LQPSSVCVGE EFQIVLSGRG FMLGSRNGSV LCTYTVNETY TTSVKPVSVQ LNSMLCPAPI LNKAGETLDV SVSFNGG Anthrax toxin receptor 2 (ATR2), also designated capillary morphogenesis gene 2 (CMG2), is a cellular receptor for anthrax toxin
- ATR2/CMG2 is a type 1 membrane protein that includes an extracellular von Willebrand factor A (VWA) domain with a metal ion-dependent adhesion site (MIDAS) motif
- ATR2/CMG2 binds to protective antigen (PA) which is one of the three monomeric proteins which are released as anthrax toxin from Bacillus anthracis
- Once bound, PA facilitates the delivery of the other two proteins, edema factor (EF) and lethal factor (LF), into the cytosol
- Mutations in the gene ATR2/CMG2 result in inhibition of binding by the vWA domain, associated with infantile systemic hyalinosis (ISH) and juvenile hyaline fibromatosis (JHF)
- ISH and JHF are rare stiff-skin syndromes characterized by hyaline desposition in various organs, especially the skin and gingiva.