FIS1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5117029-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA5117029 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
FIS1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
FIS1
Gene Alias
2010003O14Rik; CGI-135; Fis1; fis1 {ECO:0000250; FIS1 homolog; fission 1 (mitochondrial outer membrane) homolog; fission 1 (mitochondrial outer membrane) homolog (S. cerevisiae); fission 1 (mitochondrial outer membrane) homolog (yeast); fission, mitochondrial 1; H_NH0132A01.6; hFis1; Mitochondrial fission 1 protein; mitochondrial fission molecule; rFis1; tetratricopeptide repeat domain 11; tetratricopeptide repeat protein 11; TPR repeat protein 11; TTC11; UniProtKB:Q9Y3D6}
Host Species
Rabbit
Purification Method
Affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
288584, 51024, 66437
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Concentration
0.45 mg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300; pH 7.3
Gene Accession No.
P84817, Q9CQ92, Q9Y3D6
Gene Symbols
FIS1
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-122 of human TTC11/FIS1 (NP_0571522)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: HeLa, 293T, MCF7 Immunogen sequence: MEAVLNELVS VEDLLKFEKK FQSEKAAGSV SKSTQFEYAW CLVRSKYNDD IRKGIVLLEE LLPKGSKEEQ RDYVFYLAVG NYRLKEYEKA LKYVRGLLQT EPQNNQAKEL ERLIDKAMKK DG Fis1, a 17KDa integral membrane protein, is a novel member of mitochondrial fission machinery
- It consists of a central leucine-zipper domain, a coiled-coil region, a tetratricopeptide repeat domain and a C-terminal transmembrane domain
- It is a human orthologue of Fis1p (S.cerevisiae) and is localized in the outer mitochondrial membrane
- Fis1 acts as a pro-apoptotic factor and plays a vital role in the regulation of mitochondrial fission
- It interacts with DLP1 and Mdv1p and facilitates Dnm1p recruitment to the functional fission complex, thereby inducing apoptosis
- Role of Fis1 has also been implicated in growth and division of peroxisomes
- Loss of Fis1 inhibits apoptosis and results in elongation of mammalian mitochondria.