AKAP8 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5120850-Each-of-1 | In Stock | ₹ 44,811.50 |
PIPA5120850 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,811.50
GST (18%): ₹ 8,066.07
Total Price: ₹ 52,877.57
Antigen
AKAP8
Classification
Polyclonal
Conjugate
Unconjugated
Gene
AKAP8
Gene Alias
1200016A02Rik; A kinase (PRKA) anchor protein 8; A kinase anchor protein 8; AA673585; AKAP 8; AKAP 95; Akap8; AKAP-8; Akap95; AKAP-95; A-kinase anchor protein 8; A-kinase anchor protein 95 kDa; A-kinase anchor protein, 95kDa; A-kinase anchoring protein 8; AU015639; DKFZp586B1222
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10270, 56399
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1.08 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal; pH 7.3
Gene Accession No.
O43823, Q9DBR0
Gene Symbols
AKAP8
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 480-692 of human AKAP8 (NP_005849.1).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive test controls include: LO2, 293T, BxPC-3, HeLa, Jurkat, mouse thymus
- The target is usually found in the following locations: Nucleus matrix
- Immunogen sequence: HCLACDMLIP AQPQLLQRHL HSVDHNHNRR LAAEQFKKTS LHVAKSVLNN RHIVKMLEKY LKGEDPFTSE TVDPEMEGDD NLGGEDKKET PEEVAADVLA EVITAAVRAV DGEGAPAPES SGEPAEDEGP TDTAEAGSDP QAEQLLEEQV PCGTAHEKGV PKARSEAAEA GNGAETMAAE AESAQTRVAP APAAADAEVE QTDAESKDAV PTE The type II cAMP-protein kinase (PKA) is a multifunctional kinase with a broad range of substrates
- Specificity of PKA signaling is thought to be mediated by the compartmentalization of the kinase to specific sites within the cell
- To maintain this specific localization, the R subunit (RII) of PKA interacts with specific RII-anchoring proteins
- The family of RII-anchoring proteins has been designated A-kinase anchoring proteins (AKAP)
- AKAP 95, also known as AKAP 8, is a nuclear matrix protein predominantly expressed in liver, heart, pancreas, kidney and skeletal muscle
- During mitosis, AKAP 95 is recruited to the chromosomes and plays an essential role in mitotic progression
- Characteristic of its family, AKAP 95 participates in PKA signaling through an interaction with the RII regulatory subunit
- In addition, AKAP 95 forms a complex with HA95 and HDAC3 and is required for the deacetylation of Histone H3 in mitosis.