PIPA5121632
RTN1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5121632-Each-of-1 | In Stock | ₹ 17,346.10 |
PIPA5121632 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 17,346.10
GST (18%): ₹ 3,122.298
Total Price: ₹ 20,468.398
Antigen
RTN1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
RTN1
Gene Alias
0710005K15Rik; 4930441F12Rik; I79_024631; LOC100750648; MGC133250; MGC40985; Neuroendocrine-specific protein; Nsp; R75279; reticulon 1; reticulon-1; RP23-450G14.1; RTN1; Rtn1-a; Rtn1-b; Rtn1-c; S-rex
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6252
Content And Storage
-20°C
Form
Liquid
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
500 μg/mL
Formulation
PBS with 50% glycerol and 0.05% ProClin 300
Gene Accession No.
Q16799
Gene Symbols
RTN1
Immunogen
Recombinant protein Reticulon 1. The antigen corresponds to amino acid range 589-776 of the target protein.
Quantity
20 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Reticulon-1 was formerly designated NSP for Neuroendocrine-Specific-Protein, because it is specifically expressed in neural and neuroendocrine tissues
- The NSP-gene has been mapped by fluorescence in situ hybridization to human chromosome 14q21-q22
- The NSP-gene encodes three overlapping proteins, i.e
- reticulon-1A (NSP-A), reticulon-1B (NSP-B), and reticulon-1C (NSP-C)
- These proteins were found to be anchored to membranes of the endoplasmic reticulum through their common carboxy-terminal regions
- Reticulon-1A is a protein with a molecular weight of approximately 135 kDa, which occurs in various isoforms presumably depending on the degree of phosphorylation of serine residues
- In lung cancer diagnosis Reticulon-1A appeared to be a reliable marker for the detection of neuroendocrine differentiation, since most of the small cell lung carcinoma (SCLC) and carcinoid tumors showed expression of Reticulon-1A
- Reticulon-1B is a phosphoprotein with a MW of 45 kDa and is restricted to the lung cancer cell line NCI-H82
- Reticulon-1B is so far not found in human tissues
- Reticulon-1C is a protein with a MW of 23 kDa which is not phosphorylated and is found with Reticulon-1A in SCLC (cell lines) and not in non-SCLC (cell cultures).