Phospho-CtIP (Ser327) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5143626-Each-of-1 | In Stock | ₹ 41,429.50 |
PIPA5143626 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,429.50
GST (18%): ₹ 7,457.31
Total Price: ₹ 48,886.81
Antigen
Phospho-CtIP (Ser327)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Rbbp8
Gene Alias
9930104E21Rik; COM1; CtBP-interacting protein; CtIP; DNA endonuclease RBBP8; JWDS; RB binding protein 8, endonuclease; RBBP8; RBBP-8; retinoblastoma binding protein 8; retinoblastoma-binding protein 8; Retinoblastoma-interacting protein and myosin-like; RGD1308872; RIM; SAE2; SCKL2; Sporulation in the absence of SPO11 protein 2 homolog
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
5932
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
Western Blot
Concentration
0.25 mg/mL
Formulation
10mM HEPES with 100μg/mL BSA, 150mM NaCl, 50% glycerol and no preservative; pH 7.5
Gene Accession No.
Q99708
Gene Symbols
Rbbp8
Immunogen
Synthetic phospho-peptide corresponding to amino acid residues surrounding Ser327 of human CtIP, conjugated to keyhole limpet hemocyanin (KLH).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Form
Liquid
Related Products
Description
- Specific for endogenous levels of the ∽100 kDa CtIP protein phosphorylated at Ser327
- Immunolabeling is completely eliminated by treatment with lambda-phosphatase
- CtIP, a 125 kD protein, was originally found interacting with a transcription repressor, CtBP, through the PLDLS motif (CtBP-Interacting Protein) thus suggested a role in transcription
- Studies have shown that CtIP also interacts with BRCA1 protein through the c-terminus BRCT domains also suggested that CtIP is a potential tumor suppressor
- This CtIP-BRCA1 interaction can be disrupted by DNA damaging agents including UV or gamma-irradiation
- Li et al (Nature 406, 210 - 215 (2000)) have shown that ATM phosphorylates CtIP at serine residues 664 and 745, and mutation of these sites abrogates the dissociation of BRCA1 from CtIP, resulting in persistent repression of BRCA1-dependent induction of GADD45 upon ionizing radiation.