PIPA5143640
Pre-Pro-Vasopressin Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5143640-Each-of-1 | In Stock | ₹ 39,961.00 |
PIPA5143640 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,961.00
GST (18%): ₹ 7,192.98
Total Price: ₹ 47,153.98
Antigen
Pre-Pro-Vasopressin
Classification
Polyclonal
Conjugate
Unconjugated
Gene
AVP
Gene Alias
ARVP; VP
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
11998, 24221, 551
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
Lot-Specific
Formulation
10mM HEPES with 100μg/mL BSA, 150mM NaCl, 50% glycerol and no preservative; pH 7.5
Gene Accession No.
P01185, P01186, P35455
Gene Symbols
AVP
Immunogen
Synthetic peptide corresponding to key amino acid residues surrounding the cleavage sites for the human vasopressin precursor peptide, conjugated to keyhole limpet hemocyanin (KLH).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Related Products
Description
- Specific for locally produced levels of the ∽ 20 kDa uncleaved pre-pro-vasopressin protein
- Immunolabeling of the uncleaved pre-pro-vasopressin protein band is completely blocked by preadsorption of the antibody with the peptide used as antigen
- Vasopressin is a nine amino-acid peptide hormone that plays a key role in water and blood pressure homeostasis (Qureshi S., et al 2014)
- Vasopressin is the end-product of a highly processed 164 amino acid pre-pro-peptide
- Processing of the vasopressin pre-pro-peptide results in three distinct peptides with a 1:1:1 ratio: vasopressin, neurophysin II, and copeptin (Arroyo J.P
- et al, 2021)
- Vasopressin is the biologically active hormone, neurophysin II is a carrier molecule for vasopressin, and copeptin is the c-terminal glycosylated end-product
- Vasopressin has been thought to be primarily made in the brain, and the sole source of vasopressin stimulating vasopressin V2 receptors in the kidney until recent studies (Arroyo JP, et al 2022)
- This antibody specially detects uncleaved pre-pro-vasopressin, accurately identifying locally produced vasopressin versus peripheral uptake of hypothalamic vasopressin or related peptides (Arroyo J.P
- et al, 2022)
- This key research tool aided the Arroyo group in discovering immunoreactive vasopressin outside of the brain by recognizing localized vasopressin in human and mouse kidney, specifically in the distal nephron.