Phospho-IRE1 alpha (Ser724) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5143627-Each-of-1 | In Stock | ₹ 15,023.20 |
PIPA5143627 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 15,023.20
GST (18%): ₹ 2,704.176
Total Price: ₹ 17,727.376
Antigen
Phospho-IRE1 alpha (Ser724)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ERN1
Gene Alias
9030414B18Rik; AI225830; C85377; endoplasmic reticulum (ER) to nucleus signalling 1; endoplasmic reticulum to nucleus signaling 1; endoplasmic reticulum to nucleus signalling 1; endoplasmic reticulum-to-nucleus signaling 1; Endoribonuclease; ER to nucleus signalling 1; ERN1; FLJ30999; hIRE1p; inositol-requiring 1; inositol-requiring 1 alpha; inositol-requiring enzyme 1; inositol-requiring protein 1; IRE1; IRE1a; IRE1a antibody; Ire1alpha; Ire1-alpha; Ire1p; IRE1p antibody; MGC163277; MGC163279; protein kinase/endoribonuclease; RGD1559716; Serine/threonine-protein kinase; Serine/threonine-protein kinase/endoribonuclease IRE1; serine/threonine-protein kinase/endoribonuclease IRE1-like
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
78943
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
Western Blot
Concentration
∽0.25 mg/mL
Formulation
10mM HEPES with 100μg/mL BSA, 150mM NaCl, 50% glycerol and no preservative; pH 7.5
Gene Accession No.
Q9EQY0
Gene Symbols
ERN1
Immunogen
Synthetic phosphopeptide corresponding to amino acid residues surrounding the phospho Ser724 of mouse IRE1, conjugated to keyhole limpet hemocyanin (KLH).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Mouse
Form
Liquid
Related Products
Description
- Specific for endogenous levels of the ∽130 kDa GluR1 protein phosphorylated at Ser724
- Immunolabeling is completely eliminated by treatment with lambda-phosphatase
- ERN1 serine/threonine kinase or endoplasmic reticulum to nucleus signaling 1 is the ER to nucleus signaling 1 protein, a human homologue of the yeast Ire1 gene product which possesses intrinsic kinase activity and an endoribonuclease activity and it is important in endoplasmic reticulum-based stress signals
- ERN1 controls IRE1 proteolysis in mammalian cells
- ERN1 has a critical function in extraembryonic cells that is essential for fetal viability
- Specifically, IRE1 acts as the sensor of unfolded proteins in the ER that initiates transmittance of the unfolded protein signal from the ER to the nucleus by splicing XBP1 mRNA converting it into a potent unfolded-protein response transcriptional activator
- Null mutants are viable, but IRE1 is essential for viability under stress conditions that cause unfolded proteins to accumulate in the ER
- Depletion of IRE1p through the expression of a dominant negative form of IRE1p has no effect on transfected cells, but cell death via apoptosis occurs under stress conditions that cause unfolded proteins to accumulate in the ER.