NGEF Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5143696-Each-of-1 | In Stock | ₹ 45,879.50 |
PIPA5143696 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,879.50
GST (18%): ₹ 8,258.31
Total Price: ₹ 54,137.81
Antigen
NGEF
Classification
Polyclonal
Conjugate
Unconjugated
Gene
NGEF
Gene Alias
ARHGEF27; Besh3; brain-enriched SH3-domain protein Besh3; ephexin; ephexin-1; eph-interacting exchange protein; Neuronal guanine nucleotide exchange factor; Ngef; Tims2; transforming immortalised mammary epithelial sequence 2
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
246217, 25791, 53972
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Concentration
Lot-Specific
Formulation
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.
Q5BKC9, Q8CHT1, Q8N5V2
Gene Symbols
NGEF
Immunogen
Ephexin-1 synthetic peptide (coupled to carrier protein) corresponds to amino acids in the C-terminal region of mouse ephexin-1. This sequence has significant homology to the same region in human and rat ephexin-1, and has low homology to other known proteins.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Related Products
Description
- The antibody detects an 80 kDa* band corresponding to ephexin-1 in Western blots of human A431, Jurkat, and HUVEC cells, as well as rat PC12 cells and mouse brain tissue
- Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42
- Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis
- Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation
- Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension.