Phospho-PTP1B (Ser50) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5143754-Each-of-1 | In Stock | ₹ 45,879.50 |
PIPA5143754 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,879.50
GST (18%): ₹ 8,258.31
Total Price: ₹ 54,137.81
Antigen
Phospho-PTP1B (Ser50)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PTPN1
Gene Alias
CPTP1; EC 3.1.3.48; EGK_02300; hgnc9642; KIAA0283; protein tyrosine phosphatase 1B; protein tyrosine phosphatase non-receptor type 1; protein tyrosine phosphatase, non-receptor type 1; protein tyrosine phosphatase, placental; protein-protein-tyrosine phosphatase HA2; protein-tyrosine phosphatase 1B; Protein-tyrosine phosphatase HA2; PTN1; Ptp; PTP1B; PTP-1B; ptp1b protein; PTP-HA2; Ptpn1; RP5-1121H13.2; RPTPrho; tyrosine phosphatase 1b; tyrosine-phosphatase; Tyrosine-protein phosphatase non-receptor type 1; wu:fk54h03
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
19246, 24697, 5770
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
Immunocytochemistry, Western Blot
Concentration
Lot-Specific
Formulation
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.
P18031, P20417, P35821
Gene Symbols
PTPN1
Immunogen
PTP1B (Ser-50) synthetic peptide (coupled to carrier protein) corresponds to amino acids surrounding Ser-50 in human PTP1B. This sequence has significant homology to the conserved site in rat and mouse PTP1B, and has homology to conserved sites in TC-PTP and MPTP, but not other protein tyrosine phosphatase family members.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Related Products
Description
- The antibody detects a 50 kDa* doublet corresponding to PTP1B in western blots of calyculin A treated human A431 and Jurkat cells
- This reactivity is observed as a weak singlet in control cells and is not observed after lambda phosphatase treatment
- PTP1B (PTPN1) is a tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response
- It mediates dephosphorylation of EIF2AK3/PERK and in turn inactivates the protein kinase activity of EIF2AK3/PERK
- PTP1B also plays a role in CKII- and p60c-src-induced signal transduction cascades
- It regulates the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion
- PTP1B also regulates the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.