Phospho-SHP-1 (Tyr536) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5143763-Each-of-1 | In Stock | ₹ 45,879.50 |
PIPA5143763 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,879.50
GST (18%): ₹ 8,258.31
Total Price: ₹ 54,137.81
Antigen
Phospho-SHP-1 (Tyr536)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PTPN6
Gene Alias
70Z-SHP; EC 3.1.3.48; hcp; Hcph; hematopoietic cell phosphatase; hematopoietic cell protein-tyrosine phosphatase; HPTP1C; me; motheaten; protein tyrosine phosphatase, non-receptor type 6; protein-tyrosine phosphatase 1C; Protein-tyrosine phosphatase SHP-1; PTN6; Ptp1C; PTP-1C; Ptph6; PTPN6; PTPTY-42; SH2 phosphatase 1; SHP1; Shp-1; SHP-1L; SH-PTP1; Tyrosine-protein phosphatase non-receptor type 6
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
116689, 15170, 5777
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Isotype
IgG
Applications
Western Blot
Concentration
Lot-Specific
Formulation
PBS with 1mg/mL BSA, 50% glycerol and 0.05% sodium azide
Gene Accession No.
P29350, P29351, P81718
Gene Symbols
PTPN6
Immunogen
Phospho-SHP1 (Tyr-536) synthetic peptide (coupled to carrier protein) corresponding to amino acids around tyrosine 536 in human SHP1. The sequence is highly conserved in rat and mouse SHP1.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Liquid
Related Products
Description
- This antibody was cross-adsorbed to a non-specific phospho-tyrosine peptide then affinity-purified using phospho-SHP1 (Tyr-536) peptide
- The antibody detects a 68 kDa* band on SDS-PAGE immunoblots of human Jurkat cells treated with pervanadate, but is not observed in control cells
- SHP-1 (PTPN6) is a non-receptor protein tyrosine phosphatase that is expressed primarily in hematopoietic cells
- The enzyme is composed of two SH2 domains, a tyrosine phosphatase catalytic domain, and a carboxy-terminal regulatory domain
- SHP-1 removes phosphates from target proteins to downregulate several tyrosine kinase-regulated pathways
- In hematopoietic cells, the amino-terminal SH2 domain of SHP-1 binds to tyrosine phosphorylated erythropoietin receptors (EpoR) to negatively regulate hematopoietic growth
- Overexpression of SHP-1 in epithelial cells results in dephosphorylation of the Ros receptor tyrosine kinase and subsequent downregulation of Ros-dependent cell proliferation and transformation
- Following ligand binding in myeloid cells, SHP-1 associates with the IL-3R beta chain and downregulates IL-3-induced tyrosine phosphorylation and cell proliferation.