BUBR1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA5143857-Each-of-1 | In Stock | ₹ 35,422.00 |
PIPA5143857 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 35,422.00
GST (18%): ₹ 6,375.96
Total Price: ₹ 41,797.96
Antigen
BUBR1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
BUB1B
Gene Alias
AU045529; BUB1 budding uninhibited by benzimidazoles 1 homolog beta; BUB1 mitotic checkpoint serine/threonine kinase B; Bub1A; Bub1b; BUB1B, mitotic checkpoint serine/threonine kinase; BUB1beta; BUBR1; budding uninhibited by benzimidazoles 1 beta; budding uninhibited by benzimidazoles 1 homolog beta; budding uninhibited by benzimidazoles 1 homolog, beta (S. cerevisiae); hBub1; hBUBR1; MAD3/BUB1-related protein kinase; MAD3L; Mitotic checkpoint kinase MAD3L; mitotic checkpoint serine/threonine-protein kinase BUB1 beta; MVA1; Protein SSK1; SSK1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12236, 171576, 701
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Isotype
IgG
Applications
ELISA, Flow Cytometry, Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
500 μg/mL
Formulation
PBS with 4MG trehalose and 0.05MG sodium azide
Gene Accession No.
O60566, Q9Z1S0
Gene Symbols
BUB1B
Immunogen
E.coli-derived human BubR1/BUB1B recombinant protein (Position: K26-E448).
Quantity
100 μg
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Lyophilized
Related Products
Description
- Adding 0.2 mL of distilled water will yield a concentration of 500 μg/mL
- BUBR1 is a member of the Ser/Thr protein kinase family
- It is a component of the mitotic checkpoint that delays anaphase until all chromosome are properly attached to the mitotic spindle
- Compromised spindle checkpoints are thought to play an important role in genetic instability that predisposes cells to malignant transformations
- Human cells contain two related checkpoint protein kinases, evolved from the BUB1 gene; hBUBR1 and hBUB1
- They are important components of the spindle checkpoint Both kinases monitor mitotic kinetochore-microtubule interactions
- hBUBR1 is essential for normal mitotic progression as it prevents cells from entering into anaphase too early
- BUBR1 has been detected in human cancers
- It has been identified as a novel binding partner of BCSG1 (Breast Cancer-Specific Gene 1), which has been suggested to accelerate the progression of breast cancer by compromising the mitotic checkpoint control through inactivation of BUBR1.