KIR2DS3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA525667-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA525667 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
KIR2DS3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
KIR2DS3
Gene Alias
killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 3; killer cell immunoglobulin-like receptor 2DS3; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 3; KIR2DS3; MHC class I NK cell receptor; natural killer cell inhibitory receptor; natural killer-associated transcript 7; NKAT7; NKAT-7
Host Species
Rabbit
Purification Method
Antigen affinity chromatography, Protein A
Regulatory Status
RUO
Gene ID (Entrez)
3808
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Flow Cytometry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.5 mg/mL
Formulation
PBS with 0.09% sodium azide
Gene Accession No.
Q14952
Gene Symbols
KIR2DS3
Immunogen
KLH conjugated synthetic peptide between 268-295 amino acids from the C-terminal region of human KIR2DS3
Quantity
400 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
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Description
- Description Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells
- The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC)
- The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2)
- The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain
- KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals
- The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response.