PKC gamma Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA528618-Each-of-1 | In Stock | ₹ 46,769.50 |
PIPA528618 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,769.50
GST (18%): ₹ 8,418.51
Total Price: ₹ 55,188.01
Antigen
PKC gamma
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PRKCG
Gene Alias
PKC; Pkcc; PKCG; PKCgamma; PKC-gamma; PKCI; Prkc; Prkcc; PRKCG; protein kinase C gamma; protein kinase C gamma type; protein kinase C type I (gamma type); protein kinase C, gamma; RATPKCI; SCA14
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
18752, 24681, 5582
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry (Frozen), Immunohistochemistry (Paraffin), Western Blot
Concentration
1 mg/mL
Formulation
0.1M tris glycine with 10% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
P05129, P63318, P63319
Gene Symbols
PRKCG
Immunogen
Recombinant protein fragment corresponding to a region within amino acids 1 and 314 of Human PKC gamma
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: 293T, mouse brain, rat brain
- Predicted reactivity: Mouse (98%), Rat (98%), Rabbit (99%), Bovine (98%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- The PKC family of serine/threonine kinases, including PRKCG (PKC gamma), is activated intracellularly by signal transduction pathways
- In humans, at least 12 different PKC polypeptides have been identified
- These isoforms differ in primary structure, tissue distribution, subcellular localization, mode of action in vitro, response to extracellular signals, and substrate specificity
- PKC alpha, beta I, beta II, and gamma form the conventional family; their activities are Ca2+- and phospholipid-dependent
- Protein kinase C can be activated by calcium and second messenger diacylglycerol
- PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways
- PKC also serve as major receptors for phorbol esters, a class of tumor promoters
- Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells
- PKC gamma is one of the PKC family members
- This protein kinase is expressed solely in the brain and spinal cord and its localization is restricted to neurons
- It has been demonstrated that several neuronal functions, including long term potentiation (LTP) and long term depression (LTD), specifically require this kinase
- Knockout studies in mice also suggest that this kinase may be involved in neuropathic pain development
- Defects in this protein have been associated with neurodegenerative disorder spinocerebellar ataxia-14 (SCA14).