KLF10 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA528873-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA528873 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
KLF10
Classification
Polyclonal
Conjugate
Unconjugated
Gene
KLF10
Gene Alias
AI115143; Cpg20; early growth response-alpha; EGR[a]; EGRA; Egral; EGR-alpha; Gdnfif; GDNF-inducible factor; Klf10; Krueppel-like factor 10; Kruppel like factor 10; Kruppel-like factor 10; mGIF; TGFB inducible early growth response; TGFB inducible early growth response 1; TGFB-inducible early growth response protein 1; Tieg; TIEG1; TIEG-1; transcription factor GIF; Transforming growth factor-beta-inducible early growth response protein 1; zinc finger transcription factor homolog CPG20; zinc finger transcription factor TIEG
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
7071
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
ChIP Assay, Western Blot
Concentration
1 mg/mL
Formulation
PBS with 1% BSA, 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
Q13118
Gene Symbols
KLF10
Immunogen
Synthetic peptide corresponding to a region within amino acids 1 and 97 of KLF10/TIEG1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: HeLa nuclear, eGFP-human KLF10-transfected 293T
- Predicted reactivity: Rhesus Monkey (100%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- KLF10 is a nuclear protein belonging to the Sp1 C2H2-type zinc-finger protein family with three C2H2-type zinc fingers
- KLF10 is a transcriptional repressor involved in the regulation of cell growth and inhibits cell growth
- It binds to the consensus sequence 5'-GGTGTG-3' and is induced by TGF-beta thus playing a role in linking TGF-beta-mediated signaling cascades to the regulation of pancreatic epithelial cell growth
- KLF10 is involved in inducing and promoting apoptosis through the mitochondrial apoptotic pathway and may inhibit Smad7 expression in bronchial epithelial cells
- Ubiquitous expression of KLF10 is seen in most of the tissues
- Reports suggest that it may mediate up-regulation of TGFBI in VHL-deficient tumors and other cancers
- Over expression of KLF10 may be associated with renal clear cell carcinoma and other tumors
- KLF11 is a zinc finger transcription factor that binds to SP1-like sequences in epsilon- and gamma-globin gene promoters
- This binding inhibits cell growth and causes apoptosis
- Defects in this gene are a cause of maturity-onset diabetes of the young type 7 (MODY7)
- Three transcript variants encoding two different isoforms have been found for this gene.