PIASy Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA530628-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA530628 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
PIASy
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PIAS4
Gene Alias
e3 sumo- ligase pias4; E3 SUMO-protein ligase PIAS4; FLJ12419; MGC35296; Pias4; Piasg; Pias-gamma; PIASy; protein inhibitor of activated STAT 4; protein inhibitor of activated STAT PIASy; protein inhibitor of activated STAT protein 4; Protein inhibitor of activated STAT protein gamma; protein inhibitor of activated STAT protein PIASy; protein inhibitor of activated STAT, 4; RING-type E3 ubiquitin transferase PIAS4; zinc finger, MIZ-type containing 6; ZMIZ6
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
51588
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.94 mg/mL
Formulation
0.1M tris glycine with 20% glycerol and 0.01% thimerosal; pH 7
Gene Accession No.
Q8N2W9
Gene Symbols
PIAS4
Immunogen
Recombinant fragment contain a sequence corresponding to a region within amino acids 54 and 273 of PIASy
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Recommended positive controls: human PIAS4-transfected 293T
- Predicted reactivity: Chimpanzee (97%), Bovine (87%)
- Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor
- Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway
- Involved in gene silencing
- Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168
- In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations
- Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation
- [UniProt]