TCOF1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA558309-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA558309 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
TCOF1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
TCOF1
Gene Alias
AA408847; AW209012; MFD1; nucleolar trafficking phosphoprotein; Tcof1; TCS; TCS1; Treacher Collins Franceschetti syndrome 1, homolog; Treacher Collins syndrome protein; Treacher Collins syndrome protein homolog; Treacher Collins-Franceschetti syndrome 1; Treacher Collins-Franceschetti syndrome 1 homolog; treacle; Treacle protein; treacle ribosome biogenesis factor 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6949
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry
Concentration
0.1 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q13428
Gene Symbols
TCOF1
Immunogen
Recombinant protein corresponding to Human TCOF1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: ESSRISDGKK QEGPATQVSK KNPASLPLTQ AALKVLAQKA SEAQPPVART QPSSGVDSAV GTLPATSPQS TSVQAKGTNK LRKPK Highest antigen sequence identity to the following orthologs: Mouse - 37%, Rat - 32%
- Treacle is a serine/alanine-rich 1,411 amino acid nuclear phosphoprotein that interacts with upstream binding factor (UBF) and affects transcription of the ribosomal DNA gene
- Treacle is also involved in early embryonic development, particularly in the craniofacial complex, and may play a role in nucleolarcytoplasmic transport
- The Treacle protein contains three domains with unique N- and C-termini and a large central repeat domain
- Mutations in TCOF1, the gene that encodes for Treacle, cause Treacher Collins-Franceschetti syndrome (TCS), a disorder characterized by defects in craniofacial development
- Symptoms of TCS include conductive hearing loss, hypoplasia of the mandible and maxilla, downward sloping palpebral fissures and cleft palate.