IFIT5 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA566464-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA566464 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
IFIT5
Classification
Polyclonal
Conjugate
Unconjugated
Gene
IFIT5
Gene Alias
IFIT5; IFIT-5; interferon induced protein with tetratricopeptide repeats 5; interferon-induced 58 kDa protein; Interferon-induced protein with tetratricopeptide repeats 5; ISG58; P58; Retinoic acid- and interferon-inducible 58 kDa protein; retinoic acid- and interferon-inducible protein (58kD); RI58
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
24138
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
0.4 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
Q13325
Gene Symbols
IFIT5
Immunogen
Recombinant Human IFIT5
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: THNRPKGKDKL KVDELISSAI FHFKAAMERD SMFAFAYTDL ANMYAEGGQY SNAEDIFRKA LRLENITDDH KHQIHYH Highest antigen sequence identity to the following orthologs - mouse 37%, rat 39%
- Interferon-induced RNA-binding protein involved in the human innate immune response
- Has a broad and adaptable RNA structure recognition important for RNA recognition specificity in antiviral defense
- Binds precursor and processed tRNAs as well as poly-U-tailed tRNA fragments (PubMed:25092312, PubMed:23317505, PubMed:23774268)
- Specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs
- Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection
- Directly binds PPP-RNA in a non-sequence-specific manner (PubMed:23334420)
- Also recognizes and selectively binds AT-rich dsDNA (PubMed:23774268)
- Additionally, as a mediator in innate immunity, regulates positively IKK-NFKB signaling by sinergizing the recruitment of IKK to MAP3K7 (PubMed:26334375)
- [UniProt]