Ataxin 1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA572951-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA572951 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
Ataxin 1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ATXN1
Gene Alias
2900016G23Rik; alternative ataxin1; ataxin 1; Ataxin1; ataxin-1; Atx1; Atx-1; Atx-1-PB; Atxn1; C85907; CG4547; CG4547-PB; D6S504E; dAtx-1; Dmel\CG4547; Dmel_CG4547; ENSMUSG00000074917; Gm10786; OTTHUMP00000016065; SCA1; spinocerebellar ataxia 1; spinocerebellar ataxia 1 homolog; spinocerebellar ataxia type 1 protein; Spinocerebellar ataxia type 1 protein homolog
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
6310
Content And Storage
4° C, do not freeze
Form
Liquid
Applications
Immunoprecipitation, Western Blot
Concentration
0.2 mg/mL
Formulation
TBS with 0.1% BSA and 0.09% sodium azide
Gene Accession No.
P54253
Gene Symbols
ATXN1
Immunogen
The immunogen recognized by this antibody maps to a region between residue 766 and 816 of human ataxin-1 using the numbering given in entry NP_000323.2 (GeneID 6310).
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord
- Clinically, ADCA has been divided into three groups: ADCA types I-III
- ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes
- ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure' cerebellar syndrome (SCA5), are most likely homogeneous disorders
- Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions
- ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein
- The expanded repeats are variable in size and unstable, usually increasing in size when transmitted to successive generations
- The function of the ataxins is not known
- This locus has been mapped to chromosome 6, and it has been determined that the diseased allele contains 41-81 CAG repeats, compared to 6-39 in the normal allele, and is associated with spinocerebellar ataxia type 1 (SCA1)
- At least two transcript variants encoding the same protein have been found for this gene.