Phospho-ULK1 (Ser555) Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA578249-Each-of-1 | In Stock | ₹ 48,905.50 |
PIPA578249 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 48,905.50
GST (18%): ₹ 8,802.99
Total Price: ₹ 57,708.49
Antigen
Phospho-ULK1 (Ser555)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ULK1
Gene Alias
APG1; ATG 1; ATG1; ATG1 autophagy related 1 homolog; ATG1A; AU041434; Autophagy-related protein 1 homolog; C. elegans; EC:2.7.11.1; FLJ38455; hATG1; KIAA0722; mKIAA0722; Serine/threonine-protein kinase ULK1; serine/threonine-protein kinase Unc51.1; ULK 1; Ulk1; UNC 51; UNC51; unc-51 like autophagy activating kinase 1; unc-51 like kinase 1; Unc51.1; unc-51-like kinase 1
Host Species
Rabbit
Purification Method
Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
8408
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Western Blot
Concentration
0.13 mg/mL
Formulation
PBS with 1% BSA, 20% glycerol and 0.025% ProClin 300; pH 7
Gene Accession No.
O75385
Gene Symbols
ULK1
Immunogen
Recombinant protein encompassing a sequence within the center region of human ULK1 (phospho Ser555). The exact sequence is proprietary.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Control: MCF-7, MCF-7 (100 μM CCCP treatment for 2 hr) Predicted Reactivity: Mouse (100%), Rat (100%) Store product as a concentrated solution
- Centrifuge briefly prior to opening the vial
- ULK1 is a serine/threonine protein kinase that plays critical role during initial stages of autophagy which is a vital response to nutrient starvation
- The conserved C-terminal domain (CTD) of ULK1 controls the regulatory function and localization of the protein
- Knockdown of ULK1 inhibits the autophagic response as well as inhibiting rapamycin-induced autophagy consistent with a role downstream of mTOR
- ULK1 forms a complex with FIP200 and ATG13 and this complex is essential for starvation-induced autophagy
- Both FIP200 and ATG13 are critical for correct localization of ULK1 to the pre-autophagosome and stability of ULK1 protein
- ULK1 is phosphorylated by the mTOR pathway in a nutrient starvation-regulated manner.