Arginase 1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA582106-Each-of-1 | In Stock | ₹ 52,332.00 |
PIPA582106 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 52,332.00
GST (18%): ₹ 9,419.76
Total Price: ₹ 61,751.76
Antigen
Arginase 1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
ARG1
Gene Alias
AI; A-I; AI type I arginase; AI256583; Arg1; Arg-1; Arginase; arginase 1; arginase 1 liver; arginase 1, liver; arginase I; arginase, liver; Arginase1; arginase-1; HGNC:663; Liver Arginase; Liver-type arginase; PGIF; similar to arginase, type I; Type 1 Arginase; type I arginase
Host Species
Rabbit
Purification Method
Anitgen affinity chromatography, Antigen affinity chromatography
Regulatory Status
RUO
Gene ID (Entrez)
383
Content And Storage
Store at 4°C short term. For long term storage, store at -20°C, avoiding freeze/thaw cycles.
Form
Liquid
Applications
Immunohistochemistry, Western Blot
Concentration
0.2 mg/mL
Formulation
PBS with 40% glycerol and 0.02% sodium azide; pH 7.2
Gene Accession No.
P05089
Gene Symbols
ARG1
Immunogen
Recombinant protein corresponding to Human ARG1
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: TIGIIGAPFS KGQPRGGVEE GPTVLRKAGL LEKLKEQECD VKDYGDLPFA DIPNDSPFQI VKNPRSVGKA SEQLAGKVAE VKKNGRISLV LGGDHSLAIG SISGHARVHP DLGVIWVDA Arginase-1 (Arg1) is a 35 kDa enzyme converting L-arginine to urea and L-ornithine, which is the final step in the urea cycle
- The resulting polyamines are important for cell proliferation and removal of toxins that arise from protein degradation
- By degrading arginine, Arginase 1 deprives NO synthase of its substrate and down-regulates nitric oxide production
- In both human and mouse, Arginase 1 is expressed in the liver, neutrophils, myeloid derived suppressor cells (MDSC) and neural stem cells
- In human, expression in blood neutrophils but not in CCR3+ granulocytes has been reported
- In mice, expression of Arginase 1 is one of the hallmarks of alternatively activated macrophages (M2a)
- Arginase-1 may be expressed in the myeloid cells infiltrating tumors, and is typically found in the majority of hepatocellular carcinomas
- Defects in Arginase 1 are the cause of argininemia, an autosomal recessive disorder characterized by hyperammonemia.