GOLPH3 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA589000-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA589000 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
GOLPH3
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Golph3
Gene Alias
4733401N08Rik, 5730410D03Rik, AW413496, coat protein GPP34, coat-protein, Gmx33, golgi peripheral membrane protein 1, 34 kDa, Golgi phosphoprotein 3, golgi phosphoprotein 3 (coat-protein), golgi protein, golgi-associated protein, GOLPH3, GOPP1, GPP34, MIDAS, Mitochondrial DNA absence factor, trans-Golgi protein GMx33, Vps74
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
64083, 66629, 78961
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Western Blot
Concentration
1.87 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
Q9CRA5, Q9ERE4, Q9H4A6
Gene Symbols
Golph3
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-298 of human GOLPH3 (NP_0714131)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: MTSLTQRSSG LVQRRTEASR NAADKERAAG GGAGSSEDDA QSRRDEQDDD DKGDSKETRL TLMEEVLLLG LKDREGYTSF WNDCISSGLR GCMLIELALR GRLQLEACGM RRKSLLTRKV ICKSDAPTGD VLLDEALKHV KETQPPETVQ NWIELLSGET WNPLKLHYQL RNVRERLAKN LVEKGVLTTE KQNFLLFDMT THPLTNNNIK QRLIKKVQEA VLDKWVNDPH RMDRRLLALI YLAHASDVLE NAFAPLLDEQ YDLATKRVRQ LLDLDPEVEC LKANTNEVLW AVVAAFTK; Positive Samples: 22Rv1, LO2, HeLa, Mouse testis, Rat lung; Cellular Location: Cell membrane, Cytoplasmic side, Endosome, Golgi apparatus, Golgi stack membrane, Mitochondrion intermembrane space, Peripheral membrane protein, trans-Golgi network membrane GOLPH3 was initially identified as a peripheral membrane protein localized to the trans-Golgi network, but others reported it to be primarily a mitochondrial protein that regulated the mitochondrial mass through the regulation of the mitochondria-specific phospholipid cardiolipin
- GOLPH3 has since been implicated in the target of rapamycin (TOR) signaling pathway
- Its overexpression in transfected cells led to and increase in anchorage-independent growth and cell proliferation in vitro
- Furthermore, GOLPH3-transfected cells enhanced S6 Kinase activity in response to growth factor stimulation by EGF
- Simultaneously, AKT phosphorylation increased in these cells, while these events were abrogated in GOLPH3 siRNA treated cells compared to control cells, indicating the GOLPH3 can enhance signaling through TOR-associated complexes
- These results suggest that GOLPH3 is a bona fide oncogene and may be a useful target for therapeutic strategies.