CD34 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA589536-Each-of-1 | In Stock | ₹ 46,591.50 |
PIPA589536 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,591.50
GST (18%): ₹ 8,386.47
Total Price: ₹ 54,977.97
Antigen
CD34
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Cd34
Gene Alias
(E3-independent) E2 ubiquitin-conjugating enzyme R1, AU040960, CD34, CD34 antigen, CD34 molecule, CDC34, cell division cycle 34, cell division cycle 34 homolog, cluster designation 34, cluster of differentiation antigen 34, E2 ubiquitin-conjugating enzyme R1, E2-CDC34, hematopoietic progenitor cell antigen CD34, hematopoietic progenitor cell marker CD34, Mucosialin, RP11-328D5.2, sialomucin protein, type 1 transmembrane protein, UBC3, UBCH3, UBE2R1, ubiquitin carrier protein, ubiquitin conjugating enzyme E2 R1, ubiquitin-conjugating enzyme E2 R1, Ubiquitin-conjugating enzyme E2-32 kDa complementing, ubiquitin-conjugating enzyme E2-CDC34, Ubiquitin-protein ligase R1
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
12490, 305081, 947
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
3.36 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
P28906, Q64314
Gene Symbols
Cd34
Immunogen
A synthetic peptide corresponding to a sequence within amino acids 32-290 of human CD34 (NP_0010202801)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Positive Samples: Mouse brain, Mouse testis, Rat brain; Cellular Location: Membrane, Single-pass type I membrane protein Immunogen sequence: SLDNNGTATP ELPTQGTFSN VSTNVSYQET TTPSTLGSTS LHPVSQHGNE ATTNITETTV KFTSTSVITS VYGNTNSSVQ SQTSVISTVF TTPANVSTPE TTLKPSLSPG NVSDLSTTST SLATSPTKPY TSSSPILSDI KAEIKCSGIR EVKLTQGICL EQNKTSSCAE FKKDRGEGLA RVLCGEEQAD ADAGAQVCSL LLAQSEVRPQ CLLLVLANRT EISSKLQLMK KHQSDLKKLG ILDFTEQDVA SHQSYSQKT CD34 is a highly glycosylated monomeric with a molecular weight range of 111-115 kDa surface protein that is present on many stem cell populations
- CD34 is a stem cell marker although its expression on human hematopoietic stem cells is reversible
- CD34 may serve as a surface receptor that undergoes receptor-mediated endocytosis and regulates adhesion, differentiation and proliferation of hematopoietic stem cells and other progenitors
- CD34 expression is likely to represent a specific state of hematopoietic development that may have altered adhering properties with expanding and differentiating capabilities in both in vitro and in vivo conditions
- CD34 is possibly an adhesion molecule with a putative role for mediating the attachment of stem cells to the bone marrow extracellular matrix or directly to stromal cells
- Further, CD34 could act as a scaffold for the attachment of lineage specific glycans, allowing stem cells to bind to lectins expressed by stromal cells or other marrow components
- CD34 is thought to have a role in presenting carbohydrate ligands to selectins
- The intracellular chain of the CD34 antigen is a site of phosphorylation by activated protein kinase C suggesting a putative role in signal transduction
- Diseases associated with CD34 dysfunction include dermatofibrosarcoma and neurofibroma.