E6AP Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA595918-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA595918 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
E6AP
Classification
Polyclonal
Conjugate
Unconjugated
Gene
UBE3A
Gene Alias
4732496B02, 5830462N02Rik, A130086L21Rik, ANCR, AS, CTCL tumor antigen se37-2, E6AP, E6-AP, E6-AP ubiquitin protein ligase, E6AP ubiquitin-protein ligase, EPVE6AP, FLJ26981, HECT-type ubiquitin transferase E3A, HPVE6A, human papilloma virus E6-associated protein, human papillomavirus E6-associated protein, mKIAA4216, oncogenic protein-associated protein E6-AP, Renal carcinoma antigen NY-REN-54, UBE3A, ubiquitin conjugating enzyme E3A, ubiquitin protein ligase E3A, ubiquitin-protein ligase E3A
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
22215, 361585, 7337
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Western Blot
Concentration
0.13 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.
O08759, Q05086
Gene Symbols
UBE3A
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 300-590 of human UBE3A (NP_5708531)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: KLIRLWSKYN ADQIRRMMET FQQLITYKVI SNEFNSRNLV NDDDAIVAAS KCLKMVYYAN VVGGEVDTNH NEEDDEEPIP ESSELTLQEL LGEERRNKKG PRVDPLETEL GVKTLDCRKP LIPFEEFINE PLNEVLEMDK DYTFFKVETE NKFSFMTCPF ILNAVTKNLG LYYDNRIRMY SERRITVLYS LVQGQQLNPY LRLKVRRDHI IDDALVRLEM IAMENPADLK KQLYVEFEGE QGVDEGGVSK EFFQLVVEEI FNPDIGMFTY DESTKLFWFN PSSFETEGQF T; Positive Samples: 293T, SKOV3, BT-474, U-251MG, Jurkat, Mouse brain, Mouse heart, Mouse thymus, Rat brain; Cellular Location: Cytoplasm, Nucleus UBE3A (ubiquitin-protein ligase E3A, AKA E6AP) is an E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates
- Several substrates have been identified including the ARNTL/BMAL1, ARC, RAD23A, RAD23B, MCM7, annexin A1, the PML tumor suppressor, and the cell cycle regulator CDKN1B
- Additionally, UBE3A may function as a cellular quality control ubiquitin ligase by helping the degradation of the cytoplasmic misfolded proteins
- UBE3A also plays an important role in the regulation of the circadian clock
- Defects in UBE3A are a cause of Angelman syndrome (AS).