RUVBL2 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA595984-Each-of-1 | In Stock | ₹ 46,502.50 |
PIPA595984 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 46,502.50
GST (18%): ₹ 8,370.45
Total Price: ₹ 54,872.95
Antigen
RUVBL2
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Ruvbl2
Gene Alias
48 kDa TATA box-binding protein-interacting protein, 48 kDa TBP-interacting protein, 51 kDa erythrocyte cytosolic protein, CGI-46, ECP51, ECP-51, erythrocyte cytosolic protein, 51-KD, INO80 complex subunit J, INO80J, liebeskummer, lik, mp47, p47, p47 protein, Repressing pontin 52, reptin, Reptin 52, reptin52 protein, RuvB (E coli homolog)-like 2, RuvB like AAA ATPase 2, RuvB like AAA ATPase 2 S homeolog, ruvbl2, RUVBL2 protein, ruvbl2.S, ruvB-like 2, RuvB-like AAA ATPase 2, RuvB-like DNA helicase reptin, RuvB-like protein 2, RVB2, TAP54-beta, TIH2, TIP48, TIP49B, TIP60-associated protein 54-beta, wu:fi25f01, XELAEV_180378471mg, xReptin, zReptin
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
10856, 20174, 292907
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Immunocytochemistry, Immunoprecipitation, Western Blot
Concentration
0.37 mg/mL
Formulation
PBS with 50% glycerol and 0.02% sodium azide, pH 7.3
Gene Accession No.
Q9WTM5, Q9Y230
Gene Symbols
Ruvbl2
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 1-463 of human RUVBL2.
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: MATVTATTKV PEIRDVTRIE RIGAHSHIRG LGLDDALEPR QASQGMVGQL AARRAAGVVL EMIREGKIAG RAVLIAGQPG TGKTAIAMGM AQALGPDTPF TAIAGSEIFS LEMSKTEALT QAFRRSIGVR IKEETEIIEG EVVEIQIDRP ATGTGSKVGK LTLKTTEMET IYDLGTKMIE SLTKDKVQAG DVITIDKATG KISKLGRSFT RARDYDAMGS QTKFVQCPDG ELQKRKEVVH TVSLHEIDVI NSRTQGFLAL FSGDTGEIKS EVREQINAKV AEWREEGKAE IIPGVLFIDE VHMLDIESFS FLNRALESDM APVLIMATNR GITRIRGTSY QSPHGIPIDL LDRLLIVSTT PYSEKDTKQI LRIRCEEEDV EMSEDAYTVL TRIGLETSLR YAIQLITAAS LVCRKRKGTE VQVDDIKRVY SLFLDESRST QYMKEYQDAF LFNELKGETM DTS; Positive Samples: BT-474, K-562, SW480, MCF-7, 22Rv1, 293T; Cellular Location: Cytoplasm, Membrane, Nucleus, Nucleus matrix, nucleoplasm Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity
- Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A
- This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription
- This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair
- The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400
- NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage
- RUVBL2 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex
- May also inhibit the transcriptional activity of ATF2.