CYP27A1 Polyclonal Antibody, Invitrogen™
Manufacturer: Thermo Scientific
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PIPA596021-Each-of-1 | In Stock | ₹ 47,036.50 |
PIPA596021 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 47,036.50
GST (18%): ₹ 8,466.57
Total Price: ₹ 55,503.07
Antigen
CYP27A1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
CYP27A1
Gene Alias
1300013A03Rik, 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 26-hydroxylase, 5-beta-cholestane-3-alpha, 7-alpha, 12-alpha-triol 27-hydroxylase, 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 26-hydroxylase, 5-beta-cholestane-3-alpha,7-alpha,12-alpha-triol 27-hydroxylase, cholestanetriol 26-monooxygenase, cholesterol 27 hydroxylase, CP27, CTX, CYP27, CYP27A1, cyt, cytochrome P450 27, cytochrome P450 family 27 subfamily A member 1, cytochrome P450, 27, cytochrome P450, 27a1, cytochrome P450, family 27, subfamily a, polypeptide 1, cytochrome P450, subfamily XXVIIA (steroid 27-hydroxylase, cerebrotendinous xanthomatosis), polypeptide 1, Cytochrome P-450C27/25, P450C27, Sterol 26-hydroxylase, mitochondrial, sterol 27-hydroxylase, Vitamin D(3) 25-hydroxylase
Host Species
Rabbit
Purification Method
Affinity Chromatography
Regulatory Status
RUO
Gene ID (Entrez)
104086, 1593, 301517
Content And Storage
-20° C, Avoid Freeze/Thaw Cycles
Form
Liquid
Applications
Western Blot
Concentration
0.98 mg/mL
Formulation
PBS with 50% glycerol and 0.01% thimerosal, pH 7.3
Gene Accession No.
P17178, Q02318, Q9DBG1
Gene Symbols
CYP27A1
Immunogen
Recombinant fusion protein containing a sequence corresponding to amino acids 200-400 of human CYP27A1 (NP_0007751)
Quantity
100 μL
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Product Type
Antibody
Isotype
IgG
Related Products
Description
- Immunogen sequence: NQVSDMAQLF YYFALEAICY ILFEKRIGCL QRSIPEDTVT FVRSIGLMFQ NSLYATFLPK WTRPVLPFWK RYLDGWNAIF SFGKKLIDEK LEDMEAQLQA AGPDGIQVSG YLHFLLASGQ LSPREAMGSL PELLMAGVDT TSNTLTWALY HLSKDPEIQE ALHEEVVGVV PAGQVPQHKD FAHMPLLKAV LKETLRLYPV V; Positive Samples: 293T, Mouse kidney, Rat liver; Cellular Location: Mitochondrion membrane CYP27A1 participates in the degradation of cholesterol to bile acids in both the classic and acidic pathways
- [1] It is the initiating enzyme in the acidic pathway to bile acids, yielding oxysterols by introducing a hydroxyl group to the carbon at the 27 position in cholesterol
- In the acidic pathway, it produces 27-hydroxycholesterol from cholesterol whereas in the classic or neutral pathway, it produces 3beta-hydroxy-5-cholestenoic acid
- It is also involved in the metabolism of vitamin D3
- While CYP27A1 is present in many different tissues, its function in these tissues is largely uncharacterized
- In macrophages, 27-hydroxycholesterol generated by this enzyme may be helpful against the production of inflammatory factors associated with cardiovascular disease.