860506P

C6 Ceramide (d18:1/6:0)

Manufacturer: Sigma Aldrich

CAS Number: 124753-97-5

Synonym(S): N-hexanoyl-D-erythro-sphingosine

Select a Size

Pack Size SKU Availability Price
5 MG 860506P-5-MG In Stock ₹ 12,557.00
10 MG 860506P-10-MG In Stock ₹ 21,779.90

860506P - 5 MG

₹ 12,557.00

In Stock

Quantity

1

Base Price: ₹ 12,557.00

GST (18%): ₹ 2,260.26

Total Price: ₹ 14,817.26

form

powder

packaging

pkg of 1 × 10 mg (860506P-10mg)pkg of 1 × 5 mg (860506P-5mg)

manufacturer/tradename

Avanti Polar Lipids

lipid type

sphingolipids

shipped in

dry ice

storage temp.

−20°C

SMILES string

OC[C@]([H])(NC(CCCCC)=O)[C@]([H])(O)/C=C/CCCCCCCCCCCCC

InChI

1S/C24H47NO3/c1-3-5-7-8-9-10-11-12-13-14-15-16-18-19-23(27)22(21-26)25-24(28)20-17-6-4-2/h18-19,22-23,26-27H,3-17,20-21H2,1-2H3,(H,25,28)/b19-18+

InChI key

NPRJSFWNFTXXQC-VHEBQXMUSA-N

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Description

  • General description: C6 Ceramide (d18:1/6:0) is a short chain and a cell permeable ceramide. It comprises amino alcoholic chain attached to fatty acyl chain via an amide linkage.[1]
  • Application: C6 Ceramide (d18:1/6:0) has been used as a chemotherapeutic agent to test its anti-tumor effect in breast cancer cells[2] and ovarian cancer cell lines.[3] It has also been used to test chemo-sensitization effects in cancer cells.[4]
  • Biochem/physiol Actions: C6 Ceramide (d18:1/6:0) is involved in inhibiting proliferation and inducing apoptosis.[5] When used in combination with acid ceramidase inhibitor DM102, [(2R,3Z)-N-(1-hydroxyoctadec-3-en-2-yl)pivaloylamide], it favors cell death in human breast cancer cells lines.[6] C6 Ceramide may serve as an adjunct in chemotherapy.[4] It elicits anti-tumor effects via AKT (serine/threonine-specific protein kinase) dephosphorylation and α-tubulin acetylation.[3]
  • Packaging: 5 mL Amber Glass Screw Cap Vial (860506P-10mg)

SAFETY INFORMATION

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable